Actively Recruiting
VALidation of Imaging-based Liver Biomarkers in PEDiatric Patients
Led by Sahlgrenska University Hospital · Updated on 2025-10-02
550
Participants Needed
1
Research Sites
713 weeks
Total Duration
On this page
Sponsors
S
Sahlgrenska University Hospital
Lead Sponsor
Q
Queen Silvia Children's Hospital, Gothenburg, Sweden
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this observational (diagnostic validation) study is to validate imaging-based biomarkers for assessing liver involvement in pediatric patients with established or suspected liver disease. The projekt involves 3 larger studies, each with specific aims specified in detailed description below. The main study (study 1) compares imaging-based biomarkers-with liver biopsy to evaluate their correlation with histologically confirmed liver disease, including fibrosis, inflammation, and steatosis. The main question the overall project aims to answer is: • Can multiple novel imaging-based biomarkers, such as shear wave elastography (SWE), shear wave dispersion (SWD), and attenuation imaging (ATI), be used for detailed, non-invasive liver characterization in children, and if so, how should they be used?
CONDITIONS
Official Title
VALidation of Imaging-based Liver Biomarkers in PEDiatric Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients scheduled for a clinical liver biopsy at Queen Silvia Children's Hospital
- Children with any form of suspected or confirmed liver disease
- Age between 0 and 18 years
- Consent given by the child or parents to participate
- For controls: children scheduled for a kidney biopsy
- Age between 0 and 18 years
- Consent given by the child or parents to participate
You will not qualify if you...
- Technical limitations that prevent reliable ultrasound measurements
- Inability to fully understand the informed consent documents
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Department of Radiology, Queen Silvias Children´s Hospital,Gothenburg Sweden
Gothenburg, Västra Götaland County, Sweden, 41650
Actively Recruiting
Research Team
H
Hanna M Hebelka, Associate Prof.
CONTACT
C
Charlotte de Lange, Assoc.Prof.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here