Actively Recruiting
Validation of New Diagnostic Indices to Simplify Hyponatremia Therapy Assessment in Patients on Thiazide Diuretics
Led by University Hospital, Basel, Switzerland · Updated on 2026-02-11
136
Participants Needed
1
Research Sites
151 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is looking at two new parameters, aSID and ChU, to see if these can help physicians to distinguish between different causes of low sodium levels (hyponatremia) in Patients taking a medicament against high blood pressure (thiazide). Researchers also want to see if using these new parameters to decide on treatment works just as well, or better, than the current standard treatments.
CONDITIONS
Official Title
Validation of New Diagnostic Indices to Simplify Hyponatremia Therapy Assessment in Patients on Thiazide Diuretics
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Hospitalized patients presenting at University Hospital Basel
- Aged 18 years or older
- Able to give informed consent by signing
- Serum sodium level less than 133 mmol/l and serum osmolality less than 300 mOsm/kg
- Receiving treatment with thiazide or thiazide-like diuretic
You will not qualify if you...
- Symptomatic hyponatremia needing 3% hypertonic solution or intensive care
- Unable or contraindicated to participate due to acute severe cardiovascular events
- Decompensated liver cirrhosis CHILD C
- Decompensated heart failure NYHA III or higher
- Severe valve impairment
- Untreated adrenal insufficiency
- Severe kidney disease requiring dialysis
- Pregnancy or breastfeeding
- Receiving end of life care
- Unable to follow study procedures due to language, dementia, or critical illness
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University Hospital Basel
Basel, Switzerland, 4031
Actively Recruiting
Research Team
L
Laura Potasso, Dr. med. sc.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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