Actively Recruiting
Validation of Presence-IP1.0 for Detection of Consciousness Using Reduced-Montage TMS-EEG
Led by University of Wisconsin, Madison · Updated on 2026-04-13
30
Participants Needed
1
Research Sites
58 weeks
Total Duration
On this page
Sponsors
U
University of Wisconsin, Madison
Lead Sponsor
N
National Institute of Neurological Disorders and Stroke (NINDS)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study aims to validate a novel real-time algorithm (Presence-IP1.0) designed to detect consciousness from TMS-evoked EEG responses using a reduced electrode montage. Thirty healthy adult participants will undergo TMS-EEG recordings during wakefulness and sleep. The algorithm's ability to differentiate conscious from unconscious states will be evaluated against behavioral and physiological state classification. The goal is to determine whether Presence-IP1.0 achieves clinically useful accuracy for detecting consciousness using a portable, reduced-channel system.
CONDITIONS
Official Title
Validation of Presence-IP1.0 for Detection of Consciousness Using Reduced-Montage TMS-EEG
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy adults greater than or equal to 18 years
- Able to provide informed consent
- Able to undergo TMS and EEG recordings
- Able to sleep in laboratory setting
You will not qualify if you...
- History of neurological or psychiatric disorders
- Pregnancy
- Sleep disorders affecting normal sleep architecture
- Current history of poorly controlled headaches including intractable or poorly controlled migraines
- Any systemic illness or unstable medical condition that may cause a medical emergency in case of a provoked seizure (cardiac malformation, cardiac dysrhythmia, asthma, etc.)
- Possible pregnancy or plan to become pregnant in the next 6 months
- Any metal in the head
- Any metal in the body
- Any medical devices or implants (i.e. cardiac pacemaker, medication infusion pump, cochlear implant, vagal nerve stimulator) unless otherwise approved by the responsible MD
- Dental implants
- Permanent retainers
- Claustrophobia (a fear of small or closed places)
- Back problems that would prevent lying flat for several hours
- Regular night-shift work (second or third shift)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
UW School of Medicine and Public Health
Madison, Wisconsin, United States, 53792
Actively Recruiting
Research Team
M
Melanie Boly, MD, PhD
CONTACT
U
Urszula Gorska, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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