Actively Recruiting
Validation of a Regional Citrate Anticoagulation Protocol in Critically Ill Patients on Continuous Renal Replacement Therapy
Led by Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau · Updated on 2026-04-07
43
Participants Needed
1
Research Sites
101 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The objective of this study is to evaluate the effectiveness of a modified continuous renal replacement therapy (CRRT) protocol in maintaining electrolyte balance in adult patients with acute kidney injury (AKI) admitted to the intensive care unit (ICU). The study assesses whether the use of continuous venovenous hemodiafiltration (CVVHDF) with post-filter replacement under citrate anticoagulation reduces electrolyte losses and the need for electrolyte supplementation compared with standard dialytic CRRT. Participants receiving standard CRRT will be compared with those treated with the modified protocol. The duration of participation corresponds to the period during which CRRT is required. Data collection will cease once CRRT is discontinued.
CONDITIONS
Official Title
Validation of a Regional Citrate Anticoagulation Protocol in Critically Ill Patients on Continuous Renal Replacement Therapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 6518 years
- Admission to the intensive care unit (ICU)
- Diagnosis of acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT)
- Use of regional citrate anticoagulation during CRRT
You will not qualify if you...
- Known allergy or intolerance to citrate
- Contraindications to citrate anticoagulation such as severe liver failure or severe metabolic disorders affecting citrate metabolism
- Pregnancy or breastfeeding
AI-Screening
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Trial Site Locations
Total: 1 location
1
Hospital de la Santa Creu i Sant Pau
Barcelona, Barcelona, Spain, 08041
Actively Recruiting
Research Team
A
Ana Jiménez Valenzuela, Nurse
CONTACT
A
Alejandra Espinosa Guerrero, Clinical Operations Head
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
2
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