Urologic diseases in North America Project: trends in resource utilization for urinary tract infections in children.
Andrew L Freedman, Urologic Diseases in America Project
https://pubmed.ncbi.nlm.nih.gov/15711347Actively Recruiting
Phase Not Applicable
Age: 0Years - 21Years
All Genders
ID03959163
The Validity of the Quick Renal MRI in Pediatric Kidney Disease
Led by University of Wisconsin, Madison · Updated on 2024-04-03
100
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Children born with congenital urinary tract anomalies are at high risk for kidney infections and scarring, which may lead to kidney problems in adulthood. This research aims to evaluate a new rapid imaging method called quick renal MRI as a radiation-free, injection-free, and sedation-free alternative to the current standard 99mTechnetium-dimercaptosuccinic acid (99mTc-DMSA) renal scan. The study compares the quick renal MRI's accuracy to the DMSA scan in detecting acute kidney infections and scars, with results potentially easing testing burdens for children with chronic kidney disease. The study has two parts: Aim 1 involves inpatients with acute or suspected kidney infections who will have both a clinical DMSA scan and a quick MRI within one week, preferably during their hospital stay. Aim 2 includes patients visiting clinics for kidney scarring evaluations, who will have both scans scheduled within six months. All participants undergo both the DMSA and quick MRI scans to assess the quick MRI's validity. Participants aged from newborn to 21 years will be involved for durations ranging from one week (Aim 1) to six months (Aim 2). During the quick MRI, which takes about 15 minutes without injections or sedation, participants lie still while wearing protective headphones. Parents can stay with young children in the scanner for comfort. Researchers will measure how well the quick MRI detects infections and scarring compared to the DMSA scan. This includes sensitivity and specificity assessments, with the study concluding by early 2025.
CONDITIONS
Brief Title
The Validity of the Quick Renal MRI in Pediatric Kidney Disease
Who Can Participate
Age: 0Years - 21Years
All Genders
Eligibility Criteria
You may qualify if you...
- For Aim 1: Patient admitted for febrile urinary tract infection, suspected or diagnosed pyelonephritis
- For Aim 1: Undergoing clinical DMSA scan
- For Aim 2: Undergoing DMSA scans as part of routine clinical care
- For Aim 2: History of more than one urinary tract infection in the past year
- Participant age between 0 and 21 years
You will not qualify if you...
- For Aim 1: No signs of pyuria on urine analysis
- For Aim 1: Negative urine culture
- For Aim 1: Not comfortable with having a Quick MRI performed
- For both aims: Any contraindications to MRI scanning
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Diagnostic Evaluation
Duration - Up to 1 week for acute infection cases; up to 6 months for renal scarring cases
Participants undergo both the standard DMSA renal scan and the quick renal MRI to detect acute renal infections or renal scars. These imaging tests are scheduled within a short timeframe of each other depending on the participant's clinical status.
1 to 2 visits depending on clinical indication and timing of scans
Trial Site Locations
Total: 1 location
1
American Family Children's Hospital
Madison, Wisconsin, United States, 53792
Actively Recruiting
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Research Team
S
Shannon Cannon, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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Published Research Related To This Trial
Prevalence of urinary tract infection in febrile infants.
A Hoberman, H P Chao, D M Keller...
https://pubmed.ncbi.nlm.nih.gov/8320616Incidence, admission rates, and economic burden of pediatric emergency department visits for urinary tract infection: data from the nationwide emergency department sample, 2006 to 2011.
Akshay Sood, Frank J Penna, Sriram Eleswarapu...
https://pubmed.ncbi.nlm.nih.gov/26005017Trends in hospitalization for pediatric pyelonephritis: a population based study of California from 1985 to 2006.
Hillary L Copp, Meira S Halpern, Yvonne Maldonado...
https://pubmed.ncbi.nlm.nih.gov/21784477Risk factors for renal scarring and deterioration of renal function in primary vesico-ureteral reflux children: a long-term follow-up retrospective cohort study.
Mei-Ju Chen, Hong-Lin Cheng, Yuan-Yow Chiou
https://pubmed.ncbi.nlm.nih.gov/23469116Dimercaptosuccinic acid renal scintigraphy for the evaluation of pyelonephritis and scarring: a review of experimental and clinical studies.
H G Rushton, M Majd
https://pubmed.ncbi.nlm.nih.gov/1331545Antimicrobial prophylaxis for children with vesicoureteral reflux.
Pankaj Hari, Arvind Bagga
https://pubmed.ncbi.nlm.nih.gov/25207775Incidence of post-pyelonephritic renal scarring: a meta-analysis of the dimercapto-succinic acid literature.
William C Faust, Mireya Diaz, Hans G Pohl
https://pubmed.ncbi.nlm.nih.gov/19013606Renal scarring following reflux and nonreflux pyelonephritis in children: evaluation with 99mtechnetium-dimercaptosuccinic acid scintigraphy.
H G Rushton, M Majd, B Jantausch...
https://pubmed.ncbi.nlm.nih.gov/1314912The role of voiding cystourethrography in the investigation of children with urinary tract infections.
Linda C Lee, Armando J Lorenzo, Martin A Koyle
https://pubmed.ncbi.nlm.nih.gov/27713802