Actively Recruiting
Value of [68Ga]Ga-PSMA-11 PET/MRI in the Assessment of Liver Cirrhosis
Led by Massachusetts General Hospital · Updated on 2025-09-26
45
Participants Needed
1
Research Sites
157 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
A total of fifty-five (55) patients with liver cirrhosis will be enrolled in this study to produce and validate dedicated Ga-PSMA-PET/MRI acquisition protocols. The specific hypotheses include: * Ga-PSMA PET/MRI may allow robust and reproducible noninvasive in vivo quantitation of hepatic macro and microhemodynamics in cirrhotic patients * Dedicated simultaneously acquired DWI sequences might quantitate liver fibrosis and improve hemodynamic quantitation. * Ga-PSMA PET/MRI may allow noninvasive and reproducible quantitation of portal venous hypertension and predict its evolution, as well as response to treatments * Ga-PSMA PET/MRI may improve noninvasive and reproducible qualitative and quantitative assessment of liver function, structure, nodules and predict evolution of cirrhosis
CONDITIONS
Official Title
Value of [68Ga]Ga-PSMA-11 PET/MRI in the Assessment of Liver Cirrhosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Liver cirrhosis diagnosed by imaging and/or clinical data, including pathology
You will not qualify if you...
- Any contraindication to PET as per screening form
- Any contraindication to MRI as per screening form
- Allergy or contraindication to gadolinium-based contrast agent
- Pregnancy
- Breastfeeding
- Cumulative radiation exposure from research studies in the past 12 months plus this study over 50 mSv
- Unable to fit in scanner due to weight over 300 lbs or BMI over 33
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School
Charlestown, Massachusetts, United States, 02129
Actively Recruiting
Research Team
O
Onofrio Catalano, MD, Ph.D
CONTACT
D
Diandrea Galloway
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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