Actively Recruiting
Value of Bronchoalveolar Lavage with Acetylcysteine in the Treatment of Bronchiectasis.
Led by First Affiliated Hospital of Ningbo University · Updated on 2024-12-10
180
Participants Needed
1
Research Sites
102 weeks
Total Duration
On this page
Sponsors
F
First Affiliated Hospital of Ningbo University
Lead Sponsor
S
Shenzhen Third People's Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
Bronchiectasis is a clinical syndrome characterised by chronic cough, profuse sputum and/or intermittent haemoptysis, with or without shortness of breath and respiratory failure of varying severity, and abnormal thickening and dilatation of the bronchial walls as seen on lung imaging. Nebulised inhalation of N-acetylcysteine has been shown to significantly improve symptoms, shorten the length of hospital stay, reduce the rate of re-hospitalisation within six months, and improve lung function in patients with bronchiectasis with a high degree of safety. There have been no studies on the efficacy and safety of bronchoscopic irrigation with N-acetylcysteine solution in the treatment of bronchiectasis. The aim of this study was to investigate whether bronchoscopic acetylcysteine lavage combined with conventional treatment is more beneficial to patients with bronchiectasis than conventional treatment combined with conventional bronchoalveolar lavage and conventional treatment without bronchoscopy, respectively.
CONDITIONS
Official Title
Value of Bronchoalveolar Lavage with Acetylcysteine in the Treatment of Bronchiectasis.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older and 80 years or younger
- Chest CT scan showing bronchiectasis
- Experiencing an acute exacerbation of bronchiectasis with symptoms such as cough, sputum, chest tightness, or wheezing
- Agree to bronchoscopy with bronchoalveolar lavage
- Willing to participate and able to provide informed consent
You will not qualify if you...
- Severe heart or lung diseases, blood clotting problems, poor tolerance to anesthesia, psychiatric disorders, or severe neuroses that prevent bronchoscopy
- Low oxygen levels or inability to tolerate bronchoscopy or bronchoalveolar lavage during the procedure
- Unable or unwilling to cooperate with the study or deemed inappropriate by the investigator
- Significant bleeding in the airway that could worsen with bronchoalveolar lavage
- Allergy to acetylcysteine
- Missing important medical information
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The First Affiliated Hospital of Ningbo University
Ningbo, Zhejiang, China, 315010
Actively Recruiting
Research Team
Z
Zhongbo Chen
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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