Actively Recruiting

Phase Not Applicable
Age: 18Years - 80Years
All Genders
NCT07588386

The Value of Early Postoperative Colonoscopy in The Early Diagnosis of Anastomotic Leakage After Surgery for Low Colorectal Cancer

Led by Nanchong Central Hospital · Updated on 2026-05-14

140

Participants Needed

1

Research Sites

60 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

The goal of this clinical trial is to learn whether early postoperative colonoscopy is valuable in the early diagnosis of anastomotic leakage after surgery for low colorectal cancer.The main questions it aims to answer are: 1. Will the median diagnosis time of AL in the intervention group (early colonoscopy group) be significantly shorter than that in the control group? 2. Can targeted treatment (such as endoscopic vacuum therapy (EVT)) be initiated earlier in the early colonoscopy group, thereby reducing the incidence of AL and the rate of unplanned re-laparotomy? Researchers will compare the median diagnosis time of AL in the intervention group (early colonoscopy group) with the control group to observe whether early postoperative colonoscopy can detect anastomotic leakage earlier. Participants will: Experimental group (early colonoscopy group): 1. Colonoscopy will be performed on the 5th to 8th day after surgery (the surgeon will decide the specific date within this time window based on the patient's recovery). 2. Carry out adequate intestinal preparation before the examination (the specific plan is formulated according to the hospital's routine, which may involve antegrade or retrograde enema, etc., and needs to be recorded and standardized). Control group (routine observation group): 1. Receive standard postoperative management, including monitoring vital signs, abdominal signs, drainage fluid properties, etc. 2. Only when clinical symptoms suspected of anastomotic leakage occur (such as persistent fever, worsening abdominal pain, turbid drainage fluid or stool samples), CT scan, gastrointestinal angiography or diagnostic colonoscopy should be performed according to clinical indications.

CONDITIONS

Official Title

The Value of Early Postoperative Colonoscopy in The Early Diagnosis of Anastomotic Leakage After Surgery for Low Colorectal Cancer

Who Can Participate

Age: 18Years - 80Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age 18-80 years old
  • Pathologically diagnosed colorectal adenocarcinoma
  • Tumor located 15 cm or less from the anal verge
  • Undergoing laparoscopic or open radical resection with complete primary colorectal or colosal anastomosis
  • Voluntary participation with signed informed consent
Not Eligible

You will not qualify if you...

  • Confirmed distant metastasis or palliative/intraoperative metastasis (M1)
  • Unsatisfactory anastomosis or poor blood flow with reinforcement suture or preventive colostomy during surgery
  • Serious contraindications for enteroscopy such as acute myocardial infarction, severe cardiopulmonary insufficiency, or blood clotting disorders
  • Pregnant or lactating women
  • Previous colorectal surgery except for endoscopic polypectomy
  • Unable to understand or cooperate with the study process

AI-Screening

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Trial Site Locations

Total: 1 location

1

Beijing Anzhen Hospital Nanchong Hospital Affiliated to Capital Medical University

Nanchong, Sichuan, China, 637000

Actively Recruiting

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Research Team

Y

Yunhong Tian, Doctor

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

SINGLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

DIAGNOSTIC

Number of Arms

2

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