Actively Recruiting
The Value of Methotrexate in NCES for Stable Vitiligo
Led by Cairo University · Updated on 2026-03-04
20
Participants Needed
1
Research Sites
26 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn if adding a six months course of Methotrexate would improve the results of non cultured epidermal suspension (NCES) in adult patients with acral and resistant vitiligo lesions over the elbows and knees. researchers will compare results of NCES in two groups one group will receive Methotrexate for 3 months prior to the procedure and 3 months after the procedure, while the other group will not receive the drug. Patients will receive PUVA hand \& feet 3 times/week for 3 months after NCES during this period they will be followed up monthly to evaluate repigmentation.
CONDITIONS
Official Title
The Value of Methotrexate in NCES for Stable Vitiligo
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with non-segmental vitiligo (NSV) with acral or resistant lesions over the elbows and knees, that has not responded to conventional treatment
- Stability of vitiligo lesions for at least 1 year
- Age 18 years or older
You will not qualify if you...
- Segmental vitiligo
- Active vitiligo with new lesions, expansion of old lesions, confetti-like lesions, ill-defined edges, or koebnerization within the past year
- Age under 18 years
- Pregnant females
- Patients with hematologic, liver, kidney disease, or chronic infection
- Use of topical treatment within the past month or systemic treatment within the past 3 months
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Dermatology Outpatient Clinic, Kasr al Ainy Teaching Hospital, Cairo University
Cairo, Egypt
Actively Recruiting
Research Team
N
Nanis Ragab, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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