Actively Recruiting
The Value of Monitoring Circulating Cell DNA (ctDNA) in Pediatric Lymphoma: A Prospective, Multicenter Clinical Study
Led by Sun Yat-sen University · Updated on 2025-06-11
60
Participants Needed
1
Research Sites
234 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The next-generation sequencing (NGS) based on liquid biopsy has been an emerging technology to identify tumor-specific genetic aberrations in malignant tumors. The tumor tissue (FFPE) and plasma samples from the newly diagnosed pediatric lymphoma patients were collected and sequenced by 475 genes panel before, during and post treatment, to evaluate the significance of the ctDNA in efficacy prediction, predicting recurrence or mechanism of resistance to chemotherapy for pediatric lymphoma.
CONDITIONS
Official Title
The Value of Monitoring Circulating Cell DNA (ctDNA) in Pediatric Lymphoma: A Prospective, Multicenter Clinical Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Children with pediatric lymphoma (HL and NHL) requiring treatment confirmed by histological and pathological diagnosis
- Age less than 18 years old
- Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 2
- Measurable lesion on CT/MRI with longest diameter at least 1.5 cm in two perpendicular directions
- Complete clinical laboratory and pathological examination data available
- Ability to be evaluated on schedule with required samples obtainable throughout the study
- Written informed consent provided by the patient or legal representative
You will not qualify if you...
- Incomplete baseline samples including preoperative plasma, tissue, bone marrow, or cerebrospinal fluid
- Inability to obtain follow-up samples during monitoring
- Considered unsuitable for enrollment by the researcher
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Yizhuo Zhang
Guangzhou, China
Actively Recruiting
Research Team
Y
Yizhuo Zhang
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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