Actively Recruiting
Variation in Drug Interactions in People With HIV (PLWH) Aged 60 Years and Older.
Led by IRCCS Azienda Ospedaliero-Universitaria di Bologna · Updated on 2024-12-05
50
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
Sponsors
I
IRCCS Azienda Ospedaliero-Universitaria di Bologna
Lead Sponsor
G
Gilead Sciences
Collaborating Sponsor
AI-Summary
What this Trial Is About
Several cohort studies have recently shown a significant increase in the mean age of PLWH ( People Living With HIV) and in the prevalence of people in advanced age in the various cohorts, as a result of the marked increase in the mean life expectancy of these people achieved by modern antiretroviral combination therapies. However, the high prevalence of comorbidities exposes PLWH in old age to the need to take multiple drug treatments in addition to antiretroviral therapy, with the gradually increasing risk of unfavorable pharmacokinetic interactions between antiretroviral drugs and drugs taken to treat the comorbidities. This project consists of an observational, cohort, retrospective, single-center study and aims to evaluate the variation in the number and type of clinically significant drug interactions between antiretroviral therapy and concomitant therapies in PLWH aged \>60 years on stable antiretroviral therapy who, for any reason at the Clinician's discretion, have made a switch from ongoing antiretroviral therapy to the bictegravir/emtricitabine/tenofovir alafenamide regimen.
CONDITIONS
Official Title
Variation in Drug Interactions in People With HIV (PLWH) Aged 60 Years and Older.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age > 60 years
- Having non-infectious comorbidities treated with medications
- Currently receiving bictegravir/emtricitabine/tenofovir alafenamide therapy at enrollment
You will not qualify if you...
- Evidence of viral resistance to integrase inhibitors, emtricitabine, or tenofovir based on genotypic resistance testing
- Presence of severe acute infectious disease
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
IRCCS Azienda Ospedaliero-Universitaria di Bologna
Bologna, Italy, 40138
Actively Recruiting
Research Team
L
Leonardo Calza, Medicine
CONTACT
S
Silvia Cretella, Biology
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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