Actively Recruiting
Variations of Immune Infiltrate and Cell Plasticity Markers in Treated Metastatic Melanoma Patients
Led by Hospices Civils de Lyon · Updated on 2023-12-15
100
Participants Needed
1
Research Sites
482 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
COLEMAN is an opened prospective monocentric non-randomized study, initiated by the Hospices Civils de Lyon. Population targeted are patients from 18 years old with stage III or IV metastatic melanoma eligible for a metastatic melanoma treatment administered as part of usual care. The objective is to study the variations of immune infiltrate and cell plasticity before and under immunotherapy or targeted therapy. Two biopsies are done before and one month after the treatment initiation and one blood sample is done after the treatment initiation. 100 patients will be included and followed during 5 years.
CONDITIONS
Official Title
Variations of Immune Infiltrate and Cell Plasticity Markers in Treated Metastatic Melanoma Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient age �3E= 18
- Female patients must agree to use two methods of contraception; male patients need one method if their partner is of childbearing age during the study and for at least 5 months after last treatment
- Patients with metastatic stage III or IV melanoma relapse
- Eligible for metastatic melanoma treatment as part of usual care
- Willing and able to undergo cutaneous tumor biopsies (except on face, folds, or lymph nodes)
- Insured or beneficiary of a health insurance plan
- Able to provide informed consent and sign approved consent forms
- Accept conservation and use of biological samples for clinical and genetic research
You will not qualify if you...
- Being treated for hematologic tumors
- Having a documented history of autoimmune disease
- Diagnosis of ocular melanoma
- Persons under legal protection (safeguard of justice)
- Use of immunosuppressants, including corticosteroids, within 4 weeks before inclusion
AI-Screening
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Trial Site Locations
Total: 1 location
1
Service de dermatologie (Bâtiment 1A)
Lyon, France, 69495
Actively Recruiting
Research Team
S
Stéphane Dalle, Pr
CONTACT
M
Myrtille Le Bouar, MSc
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
OTHER
Number of Arms
1
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