Actively Recruiting
Vascular Endothelial Dysfunction in Sleep Apnea
Led by Columbia University · Updated on 2026-02-13
110
Participants Needed
1
Research Sites
229 weeks
Total Duration
On this page
Sponsors
C
Columbia University
Lead Sponsor
N
National Heart, Lung, and Blood Institute (NHLBI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This double-blind placebo-controlled parallel group randomized study design will be used to test whether 4 weeks of atorvastatin 10 mg daily reduces levels of inflammatory markers in OSA patients treated with CPAP (standard of care). The purpose of this study is to investigate: 1) whether statins reduce endothelial inflammation and pro-thrombotic conditions in OSA, including in patients adherent to CPAP (Aim 1); and 2) whether statins reduce endothelial inflammation and pro-thrombotic conditions by improving endothelial cholesterol metabolism and trafficking in OSA (Aim 2).
CONDITIONS
Official Title
Vascular Endothelial Dysfunction in Sleep Apnea
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 18 years or older
- Newly diagnosed with obstructive sleep apnea (OSA) and never treated with CPAP
- OSA defined as apnea-hypopnea index (AHI) of 5 or more events per hour of sleep
You will not qualify if you...
- History of coronary artery disease, heart failure, stroke, diabetes, malignancy, chronic pulmonary, kidney or rheumatologic disease
- Muscle pain or fatigue
- Smoking within the past 5 years
- Regular use of any medications
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Columbia University Irving Medical Center
New York, New York, United States, 10032
Actively Recruiting
Research Team
S
Sanja Jelic, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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