Actively Recruiting
Vascular Function and Oxidative Stress in Emergency Medical Responders
Led by University of Delaware · Updated on 2025-05-22
45
Participants Needed
1
Research Sites
20 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to characterize blood vessel function and oxidative stress (a harmful condition that damages cells and tissues) in emergency medical technicians (EMTs). The main questions it aims to answer are: 1. Does an overnight shift work in emergency medical technicians reduce blood vessel function and increase oxidative stress? 2. Can supplementing with antioxidants help reduce the negative effects of night shift work in emergency medical technicians? Researchers will compare antioxidants to a placebo (a look-alike substance that contains no drug) to see if antioxidants work in reducing the negative effects of night shift work in emergency medical technicians. Participants will: 1\. Report to the lab two separate times following an overnight shift to assess blood vessel functioning and oxidative stress 3. Take an antioxidant supplement or placebo during each night of shift work.
CONDITIONS
Official Title
Vascular Function and Oxidative Stress in Emergency Medical Responders
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Body mass index between 18.5 and <35 kg/m²
- Seated resting systolic blood pressure < 140 mmHg and diastolic blood pressure < 90 mmHg
- Active first responder working shift schedules (e.g., emergency medical responders, BLS EMTs, A-EMTs, paramedics)
- At least 1 year of shift work experience
- Works at least 4 night shifts per month
You will not qualify if you...
- Unable or unwilling to give consent
- Diagnosed with chronic diseases such as high blood pressure, heart disease, diabetes, cancer, or kidney disease
- Diagnosed with sleep disorders like insomnia, restless leg syndrome, or sleep apnea
- Currently taking melatonin, sleep aids, or supplements/medications that affect sleep patterns without a 72-hour washout
- Resting blood pressure over 140/90 mmHg
- Body mass index less than 18.5 or greater than 35 kg/m²
- Currently pregnant or breastfeeding (women only)
- Use of tobacco, nicotine products, or illicit drugs in the past month
AI-Screening
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Trial Site Locations
Total: 1 location
1
University of Delaware
Newark, Delaware, United States, 19713
Actively Recruiting
Research Team
A
Alexs Matias, MS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
OTHER
Number of Arms
2
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