Actively Recruiting
Vascular Mechanisms, Functional Outcomes, & Exercise Among Persons With Multiple Sclerosis With Hypertension
Led by University of Massachusetts, Boston · Updated on 2025-08-22
80
Participants Needed
1
Research Sites
119 weeks
Total Duration
On this page
Sponsors
U
University of Massachusetts, Boston
Lead Sponsor
U
University of Illinois at Chicago
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this study is to determine if 12 weeks of cycling exercise training at home will improve three parameters: 1) blood pressure, 2) cognition, and 3) walking ability among persons with multiple sclerosis who have high blood pressure, when compared to a group that engages in a 12-week home-based stretching program. The main questions this study aims to answer are: 1. Can home-based cycling exercise training improve blood pressure by increasing blood vessel dilation in people with multiple sclerosis? 2. Can cycling exercise training improve cognition and walking mobility in people with multiple sclerosis by improving blood pressure? The investigators will compare home-based cycling training to stretching to see if cycling training improves cognition, walking mobility, blood pressure, and fitness in people with multiple sclerosis. Participation in this study will take 13-14 weeks, with participants being randomized (like flipping a coin, a 50-50 chance of being in either group) to the home-based cycling training or the stretching group. All participants will be asked to * Visit the laboratory two times, one before the beginning of the intervention (home-base training and stretching group) and one at the end of the intervention. * During visits, participants will complete tests related to cognition, walking mobility, blood pressure and fitness.
CONDITIONS
Official Title
Vascular Mechanisms, Functional Outcomes, & Exercise Among Persons With Multiple Sclerosis With Hypertension
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Persons with confirmed multiple sclerosis diagnosis with Expanded Disability Status Scale scores of 4-6.5
- Hypertension defined as elevated or stage 1 or 2 per 2017 American Heart Association guidelines (systolic > 120 mmHg or diastolic > 80 mmHg)
- Physically inactive individuals (less than 60 minutes of physical activity per week)
- Body mass index less than 40 kg/m2
- Not confined to a wheelchair
- Multiple sclerosis relapse at least 30 days prior
- Stable pharmacotherapy
You will not qualify if you...
- Additional cardiovascular comorbidities
- Type 1 diabetes mellitus
- Physician disapproval to participate
- Lack of space at home to fit a cycle ergometer
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
UMass Boston
Boston, Massachusetts, United States, 02125
Actively Recruiting
Research Team
T
Tracy Baynard, PhD
CONTACT
J
Joao L Maroco, MS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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