Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
NCT06554340

Vascular Mechanisms, Functional Outcomes, & Exercise Among Persons With Multiple Sclerosis With Hypertension

Led by University of Massachusetts, Boston · Updated on 2025-08-22

80

Participants Needed

1

Research Sites

119 weeks

Total Duration

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Sponsors

U

University of Massachusetts, Boston

Lead Sponsor

U

University of Illinois at Chicago

Collaborating Sponsor

AI-Summary

What this Trial Is About

The goal of this study is to determine if 12 weeks of cycling exercise training at home will improve three parameters: 1) blood pressure, 2) cognition, and 3) walking ability among persons with multiple sclerosis who have high blood pressure, when compared to a group that engages in a 12-week home-based stretching program. The main questions this study aims to answer are: 1. Can home-based cycling exercise training improve blood pressure by increasing blood vessel dilation in people with multiple sclerosis? 2. Can cycling exercise training improve cognition and walking mobility in people with multiple sclerosis by improving blood pressure? The investigators will compare home-based cycling training to stretching to see if cycling training improves cognition, walking mobility, blood pressure, and fitness in people with multiple sclerosis. Participation in this study will take 13-14 weeks, with participants being randomized (like flipping a coin, a 50-50 chance of being in either group) to the home-based cycling training or the stretching group. All participants will be asked to * Visit the laboratory two times, one before the beginning of the intervention (home-base training and stretching group) and one at the end of the intervention. * During visits, participants will complete tests related to cognition, walking mobility, blood pressure and fitness.

CONDITIONS

Official Title

Vascular Mechanisms, Functional Outcomes, & Exercise Among Persons With Multiple Sclerosis With Hypertension

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Persons with confirmed multiple sclerosis diagnosis with Expanded Disability Status Scale scores of 4-6.5
  • Hypertension defined as elevated or stage 1 or 2 per 2017 American Heart Association guidelines (systolic > 120 mmHg or diastolic > 80 mmHg)
  • Physically inactive individuals (less than 60 minutes of physical activity per week)
  • Body mass index less than 40 kg/m2
  • Not confined to a wheelchair
  • Multiple sclerosis relapse at least 30 days prior
  • Stable pharmacotherapy
Not Eligible

You will not qualify if you...

  • Additional cardiovascular comorbidities
  • Type 1 diabetes mellitus
  • Physician disapproval to participate
  • Lack of space at home to fit a cycle ergometer

AI-Screening

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Trial Site Locations

Total: 1 location

1

UMass Boston

Boston, Massachusetts, United States, 02125

Actively Recruiting

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Research Team

T

Tracy Baynard, PhD

CONTACT

J

Joao L Maroco, MS

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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