Actively Recruiting
Vascular Regenerative Cell Exhaustion in Adults with Peripheral Artery Disease (PAD-VRCE)
Led by Canadian Medical and Surgical Knowledge Translation Research Group · Updated on 2024-10-04
40
Participants Needed
2
Research Sites
39 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
PAD-VRCE is an observational, cross-sectional, two arm study aimed at determining if the presence of peripheral artery disease (PAD) can influence the number of circulating regenerative cells in blood. From peripheral blood samples, circulating progenitor cell content will be assessed via flow cytometry and compared between individuals with PAD and individuals without PAD. Ultimately, this study plans to evaluate the relationship between PAD, vascular regenerative cell exhaustion and overall cardiovascular health.
CONDITIONS
Official Title
Vascular Regenerative Cell Exhaustion in Adults with Peripheral Artery Disease (PAD-VRCE)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 80 years who meet either: clinically significant symptomatic PAD with ankle brachial index less than 0.85, or no history of PAD
- Willing and able to provide written informed consent and comply with study procedures
You will not qualify if you...
- Unable or unwilling to provide written informed consent or peripheral blood sample
- Life-threatening disease expected to cause death within two years
- Any malignancy not considered cured (no recurrence for 5 years), except basal cell carcinoma of the skin
- Uncontrolled hypertension
- New York Heart Association Class IV heart failure
- Active liver disease or dysfunction
- Active kidney disease or dysfunction
- History of hemorrhagic stroke or major bleeding disorder
- White blood cell count of 15x10^9/L or higher
- Active infectious disease requiring systemic antibiotics or antiviral agents
- Known acquired immunodeficiency syndrome (e.g., HIV)
- Use of oral steroids or other immunosuppressive agents
- Treated autoimmune disorders
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
North York Diagnostic and Cardiac Centre
North York, Ontario, Canada, M6B1N6
Actively Recruiting
2
Diagnostic Assessment Centre
Scarborough Village, Ontario, Canada, M1S4N6
Actively Recruiting
Research Team
J
Jack Casey
CONTACT
A
Aishwarya Krishnaraj, BScH
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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