Actively Recruiting
Venetoclax Combined With CACAG Regimen Versus "3+7" Regimen in the Treatment of Acute Monocytic Leukemia
Led by Chinese PLA General Hospital · Updated on 2026-04-06
204
Participants Needed
3
Research Sites
217 weeks
Total Duration
On this page
Sponsors
C
Chinese PLA General Hospital
Lead Sponsor
A
Air Force Medical Center of PLA
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study is a multicenter, randomized, prospective Phase II clinical trial designed to compare the effectiveness of two treatment approaches for patients with acute monocytic leukemia.
CONDITIONS
Official Title
Venetoclax Combined With CACAG Regimen Versus "3+7" Regimen in the Treatment of Acute Monocytic Leukemia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Voluntary participation with signed informed consent and willingness to follow study procedures
- Age between 14 and 60 years
- Diagnosis of acute monocytic leukemia per 2016 WHO classification, excluding acute promyelocytic leukemia
- No history of severe allergic reactions
- Liver function with ALT and AST less than or equal to 2.5 times the upper limit of normal (ULN) and total bilirubin less than or equal to 2 times ULN
- Renal function with serum creatinine less than or equal to 1.5 times ULN
- No uncontrolled infection or severe psychiatric disorder
- Eastern Cooperative Oncology Group (ECOG) performance status 0 to 3
- Life expectancy of at least 4 months
You will not qualify if you...
- Known allergy or contraindication to any study drug
- Pregnancy or breastfeeding
- Active infection
- Long-term smoking or alcohol abuse that may affect study evaluation
- Psychiatric illness or other condition preventing informed consent or compliance
- Major organ surgery within 6 weeks before enrollment
- Abnormal liver function with total bilirubin greater than 2 times ULN or ALT/AST greater than 2.5 times ULN
- Abnormal renal function with serum creatinine greater than 1.5 times ULN
- Any other condition deemed unsuitable for the study by the investigator such as poor compliance or substance abuse
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
Air Force Medical Center, PLA
Beijing, China
Actively Recruiting
2
Chinese PLA General Hospital
Beijing, China
Actively Recruiting
3
PLA Strategic Support Force's Characteristic Medical Center
Beijing, China
Actively Recruiting
Research Team
L
Liping Dou, Doctor
CONTACT
D
Daihong Liu, Doctor
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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