Actively Recruiting
The Venous Distension Reflex and Orthostatic Hypertension
Led by Milton S. Hershey Medical Center · Updated on 2026-03-30
30
Participants Needed
1
Research Sites
337 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research is being done to find out whether distension of veins in legs will cause a rise in blood pressure (orthostatic hypertension).
CONDITIONS
Official Title
The Venous Distension Reflex and Orthostatic Hypertension
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Are capable of giving informed consent
- Are of any race or ethnicity
- Are fluent in written and spoken English
- Whose history and physical exam did not uncover any exclusion criteria
- Are 18 years of age
- For subjects with elevated standing blood pressure: systolic blood pressure during standing is at least 10 mmHg higher than when lying down
- Patients with stage I hypertension without other chronic diseases may be included
- For normal subjects without elevated standing blood pressure: change in systolic blood pressure by standing is within ±5 mmHg from lying down
- Matched gender, similar age and body mass index (within 10%) to participants with elevated standing blood pressure
- Free of acute or chronic medical conditions
You will not qualify if you...
- Age less than 18 years
- Are a pregnant or nursing woman
- Are a prisoner, institutionalized individual, or unable to consent
- Have chronic diseases such as heart, lung, neuromuscular disease, or cancer other than stage I hypertension
- Have orthostatic hypotension or a history of fainting (syncope)
- Current smoker
- History of blood clots
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Penn State Milton S. Hershey Medical Center
Hershey, Pennsylvania, United States, 17033
Actively Recruiting
Research Team
J
Jian Cui, PhD
CONTACT
K
Kris Gray
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
4
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