Actively Recruiting
Ventilator Pressure and Optimization of Compliance and Hemodynamics
Led by University of Alabama at Birmingham · Updated on 2026-05-11
24
Participants Needed
1
Research Sites
47 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
In preterm infants \< 34 weeks' gestation at birth receiving respiratory support with invasive positive pressure ventilation, the positive end-expiratory pressure (PEEP) of best compliance will increase the cardiac output and improve oxygenation. This study may emphasize using point-of-care echocardiography along with electrical impedance tomography (EIT) to optimize ventilator settings in preterm infants. Infants will be randomized to a 4-hour crossover period of increasing and decreasing PEEP in random order from baseline to determine compliance, oxygenation, and cardiac hemodynamics at each step using echocardiography (ECHO) and EIT measurements. There will be a 15-minute washout period after changes prior to data collection.
CONDITIONS
Official Title
Ventilator Pressure and Optimization of Compliance and Hemodynamics
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Preterm infants born before 34 weeks gestation receiving conventional mechanical ventilation or high-frequency jet ventilation
- Post-natal age greater than 7 days and less than 1 month
- Gestational age between 21 and 34 weeks
- Written informed consent obtained from legal guardian
You will not qualify if you...
- Blood culture-positive sepsis
- Congenital anomalies affecting respiration
- Cyanotic or ductal-dependent congenital heart disease
- Newborns deemed too unstable for study by neonatology attending
- Newborns on pressors or steroids for cardiac support
- Infants on non-invasive ventilation or with significant bronchopulmonary dysplasia and pulmonary hypertension
- Open skin wounds or abrasions on the chest wall
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Univerisity of Alabama
Birmingham, Alabama, United States, 35233
Actively Recruiting
Research Team
K
Kulsajan S Bhatia, MD
CONTACT
C
Colm P Travers, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
2
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