Actively Recruiting
Ventilator Trigger Sensitivity Adjustment Versus Threshold Inspiratory Muscle Training on Arterial Blood Gases
Led by Cairo University · Updated on 2024-12-17
45
Participants Needed
1
Research Sites
82 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The aim of the current study is to compare the effect of ventilator trigger sensitivity adjustment versus threshold inspiratory muscle training on arterial blood gases in mechanically ventilated patients.
CONDITIONS
Official Title
Ventilator Trigger Sensitivity Adjustment Versus Threshold Inspiratory Muscle Training on Arterial Blood Gases
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Difficult to wean Guillain-Barre patients who have been on mechanical ventilation for at least 48 hours and failed the first spontaneous breathing trial, possibly requiring up to 3 trials or 7 days to wean successfully
- Age over 18 years
- Both males and females are eligible
- Ventilator mode must be pressure support with FiO2 less than or equal to 0.5, PEEP less than 8-10 cm/H2O, and respiratory rate below 25
- Conscious and oriented with Glasgow Coma Score 13 or higher
- Alertness level titrated to a Riker Sedation Agitation Score of 4
- Blood pH greater than 7.25 and arterial oxygen saturation above 90%
- Cardiovascular stability
- Maximal inspiratory pressure between 15 to 30 cm H2O and ability to trigger spontaneous breaths on ventilator
You will not qualify if you...
- Persistent hemodynamic instability such as life-threatening arrhythmias or acute heart failure
- Severe breathlessness when breathing spontaneously
- Any progressive neuromuscular disease with a non-stationary course that would affect inspiratory muscle training
- Spinal cord injury
- Skeletal pathologies like scoliosis, flail chest, or spinal instrumentation impairing chest wall or rib movement
- Patients under heavy sedation or with respiratory muscle paralysis
- High peak airway pressure indicating barotrauma
- Body mass index (BMI) of 40 or higher
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Kasr Al Ainy School of Medicine
Cairo, Egypt
Actively Recruiting
Research Team
E
Elmasry
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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