Actively Recruiting
Ventilatory and Perfusion Abnormalities in Individuals With Post-Acute Sequelae of SARS-CoV-2 Infection
Led by Tufts Medical Center · Updated on 2025-07-20
40
Participants Needed
1
Research Sites
186 weeks
Total Duration
On this page
Sponsors
T
Tufts Medical Center
Lead Sponsor
4
4DMedical
Collaborating Sponsor
AI-Summary
What this Trial Is About
Prospective cohort study to evaluate the utility of quantitative CT analysis to assess ventilation and perfusion defects in patients with Post-acute Sequelae of SARS-CoV-2 (PASC) and functional limitations
CONDITIONS
Official Title
Ventilatory and Perfusion Abnormalities in Individuals With Post-Acute Sequelae of SARS-CoV-2 Infection
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Self-reported or documented SARS-CoV-2 infection by RT-PCR or Antigen testing more than 3 months ago, or no history of SARS-CoV-2 infection for control group
- Normal or mild abnormalities on baseline Pulmonary Function Tests (PFTs)
- New or worsening symptoms of chronic fatigue, dyspnea, or exercise intolerance after COVID-19 with unclear cause (for PASC group)
You will not qualify if you...
- SARS-CoV-2 infection by RT-PCR or Antigen testing within the last 3 months
- Inability to provide consent or non-English speaking
- Pregnancy
- Any respiratory infection in last 4 weeks
- Pulmonary Function Test relative contraindications
- History of major cardiovascular, pulmonary, renal, hepatic, autoimmune or neuromuscular disease including asthma, COPD, interstitial lung disease, heart failure, pulmonary arterial hypertension, or prior pulmonary embolism
- Active malignancy undergoing treatment or history of malignancy involving the lung
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Tufts Medical Center
Boston, Massachusetts, United States, 02111
Actively Recruiting
Research Team
B
Bipin Malla
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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