Actively Recruiting
Quantitative Computed Tomography to Assess Ventilatory and Perfusion Abnormalities in Individuals With Post-Acute Sequelae of SARS-CoV-2 Infection
Led by Tufts Medical Center · Updated on 2025-07-20
40
Participants Needed
1
Research Sites
30 weeks
Total Duration
On this page
Sponsors
T
Tufts Medical Center
Lead Sponsor
4
4DMedical
Collaborating Sponsor
AI-Summary
What this Trial Is About
This research aims to describe lung ventilation and blood flow abnormalities in people experiencing Post-acute Sequelae of SARS-CoV-2 (PASC), who have ongoing symptoms such as fatigue, shortness of breath, and exercise intolerance after COVID-19. The study compares these patients to two control groups: those who fully recovered from COVID-19 without lasting symptoms and healthy individuals without any history of COVID-19. The goal is to better understand lung function changes related to PASC using advanced imaging and physical assessments. Participants will undergo quantitative computed tomography (CT) scans of the chest during both inhaling and exhaling to measure regional lung ventilation and blood volume distribution. Along with the CT scans, participants complete questionnaires and perform pulmonary function tests and a six-minute walk test. These assessments help describe lung ventilation and perfusion patterns for comparison among the three groups. During the study visit, participants will complete symptom questionnaires and undergo lung function testing, a six-minute walk test, and a low-dose chest CT scan. Researchers will measure lung ventilation, blood volume distribution, severity of breathlessness and fatigue, quality of life, and walking distance. The study involves a single day of testing with no intervention treatments. Participants will be monitored for differences in lung function and symptoms among those with PASC and control groups.
CONDITIONS
Brief Title
Ventilatory and Perfusion Abnormalities in Individuals With Post-Acute Sequelae of SARS-CoV-2 Infection
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 or older
- Self-reported or documented COVID-19 infection by RT-PCR or Antigen testing more than 3 months ago, or no history of COVID-19 (control group only)
- Normal or mild abnormalities on baseline pulmonary function tests
- New or worsening symptoms of chronic fatigue, shortness of breath, or exercise intolerance after COVID-19 with unclear cause (PASC group only)
You will not qualify if you...
- COVID-19 infection by RT-PCR or Antigen testing within the last 3 months
- Inability to provide consent or non-English speaking
- Pregnancy
- Any respiratory infection in the last 4 weeks
- Contraindications to pulmonary function tests
- History of major cardiovascular, pulmonary, renal, hepatic, autoimmune, or neuromuscular diseases including asthma, COPD, interstitial lung disease, heart failure, pulmonary arterial hypertension, or prior pulmonary embolism
- Active cancer treatment or history of lung cancer
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants undergo questionnaires, pulmonary function tests, 6-minute walk tests, and low dose chest CT scans to assess lung ventilation and perfusion abnormalities.
1 visit (in-person)
Trial Site Locations
Total: 1 location
1
Tufts Medical Center
Boston, Massachusetts, United States, 02111
Actively Recruiting
Research Team
B
Bipin Malla
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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