Actively Recruiting
Ventilatory Settings and Monitoring Variables Associated With Weaning Failure in Critically Ill Patients
Led by Hospital Italiano de Buenos Aires · Updated on 2025-03-17
1077
Participants Needed
1
Research Sites
86 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Mechanical ventilation (MV) is essential in managing acute respiratory failure. Its duration is a crucial aspect since both, unnecessary prolongation and premature withdrawal have deleterious effects on patient outcomes in the ICU. The process of weaning refers to the set of procedures and evaluations carried out to discontinue MV. Regardless of the definition used, within the population undergoing weaning, there is a group of patients who successfully pass the daily screening but fail the spontaneous breathing trial (SBT) or the separate attempt (SA). In Argentina, this figure is 39.5%, and 31.4% in patients with COVID-19. On the other hand, another group of patients successfully passes the SA, is extubated, but fails in post-extubation. This failure rate varies in the literature, ranging from approximately 10 to 20%. In our country, this figure is 16% in the general population and rises to 29.7% in COVID-19 patients. Additionally, this population is divided into those who cannot tolerate ventilation without an artificial airway due to upper airway patency issues (such as laryngeal edema), i.e., "airway failure," and those who experience acute respiratory failure. In 2023, the WEAN SAFE study reported novel findings regarding variables associated with weaning failure. In multivariable analysis, it was found that the MV settings and monitoring variables at the time of the first SBT - respiratory rate, positive end-expiratory pressure (PEEP), dynamic airway pressure difference (peak pressure (Ppeak) minus PEEP) on the day of the SA - were associated with weaning failure. In this context, the investigators will conduct a retrospective cohort study, whose primary objective will be to assess which MV settings and monitoring variables are associated with weaning failure. \*\*Primary Objective\*\* To determine if there are any MV settings or monitoring variables that are associated with extubation failure. \*\*Secondary Objective\*\* To determine if there are any MV settings or monitoring variables that are associated with failure in the first SBT.
CONDITIONS
Official Title
Ventilatory Settings and Monitoring Variables Associated With Weaning Failure in Critically Ill Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Over 18 years
- Mechanical ventilation for at least 48 hours, regardless of cause
- Undergone at least one extubation, regardless of outcome
- Had at least one spontaneous breathing trial during ICU stay, regardless of outcome
You will not qualify if you...
- Mechanical ventilation records with incorrect or inconsistent data
- Lack of adequate or continuous monitoring during the weaning process
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Hospital Italiano de Buenos Aires
Buenos Aires, Argentina, 1199
Actively Recruiting
Research Team
E
Emilio M Steinberg, RT
CONTACT
D
Damián E Steinberg, RT
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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