Ventilatory Settings and Monitoring Variables Associated With Weaning Failure in Critically Ill Patients: A Retrospective Study

What this Trial Is About

Mechanical ventilation is crucial for managing acute respiratory failure, but the timing of its removal, known as weaning, is vital because both prolonging and prematurely stopping ventilation can harm patient outcomes in the ICU. This research aims to identify which ventilator settings and monitoring variables are linked to weaning failure, including extubation failure and failure during spontaneous breathing trials, especially in critically ill patients who have undergone mechanical ventilation. The study focuses on data from patients in intensive care units, including those with COVID-19, where weaning failure rates have been notably high. This is a retrospective observational study that will analyze mechanical ventilation settings and monitoring data collected during the weaning process. The study includes patients who have been mechanically ventilated for at least 48 hours, have undergone at least one extubation attempt, and have completed at least one spontaneous breathing trial during their ICU stay. Researchers will assess variables such as respiratory rate, positive end-expiratory pressure, and airway pressure differences to understand their association with weaning outcomes. Participants' medical records will be reviewed to examine ventilator parameters and clinical monitoring data linked to extubation failure within 7 days and spontaneous breathing trial failure immediately after the trial. The study will evaluate causes of reintubation and related factors to improve understanding of weaning failure. Since this is a retrospective study, participants are not actively involved, but their clinical data will be analyzed to measure these outcomes. The study is expected to run until August 2026.

Ventilatory Settings and Monitoring Variables Associated With Weaning Failure in Critically Ill Patients