Actively Recruiting
Vericiguat in Patients With Coronary Microvascular Dysfunction Causing Stable Chest Pain (V-COM)
Led by The University of Hong Kong · Updated on 2025-10-07
94
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a randomised controlled trial to determine the effectiveness of Vericiguat to improve stress myocardial blood flow (MBF) and myocardial perfusion reserve as measured by cardiac magnetic resonance (CMR) imaging.
CONDITIONS
Official Title
Vericiguat in Patients With Coronary Microvascular Dysfunction Causing Stable Chest Pain (V-COM)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Stable recurrent chest pain
- Age between 40 and 75 years
- Coronary CT angiogram or catheter coronary angiogram within 6 months showing non-obstructive coronary artery disease (less than 50% stenosis or fractional flow reserve above 0.8)
- Stress CMR myocardial perfusion reserve less than 2.19 or stress myocardial blood flow less than 2.19 ml/g/min
- Female participants must not be pregnant or breastfeeding, or if women of childbearing potential, agree to follow contraceptive guidance during and for at least 1 month after the study intervention
You will not qualify if you...
- Systolic blood pressure below 100 mm Hg
- Current use of soluble guanylate cyclase stimulators or phosphodiesterase type 5 inhibitors
- Known allergy or sensitivity to soluble guanylate cyclase stimulators
- Use of long-acting nitrates
- Known cardiomyopathy, complex congenital heart disease, endocarditis, or pericarditis
- Acute coronary syndrome or coronary revascularization within 60 days prior to randomisation, or indication for revascularization at randomisation
- Symptomatic carotid stenosis, transient ischemic attack, or stroke within 60 days prior to randomisation
- Estimated glomerular filtration rate below 30 mL/min/1.73m2
- Malignancy or other non-cardiac condition limiting life expectancy to less than 3 years
- Implanted devices not compatible with MRI
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The University of Hong Kong
Hong Kong, Hong Kong
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
2
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