Actively Recruiting
Veteran-Centered Care for Advanced Liver Disease (Vet-CALD)
Led by VA Office of Research and Development · Updated on 2026-02-06
450
Participants Needed
8
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Advanced liver disease is a serious illness that disproportionately affects Veterans, many of whom hope for curative liver transplantation. However, too few receive a transplant and most continue to suffer from increasing symptoms and hospitalizations. The proposed project uses a whole person, Veteran-centered approach that identifies Veterans with advanced liver disease using a population-based health management system and integrates curative and early supportive care using a telemedicine-based nurse care counselor to (1) discuss patient's understanding of illness severity and prognosis, (2) identify priorities and care preferences and (3) align curative and supportive care options to achieve patient priorities. Study outcomes include changes in (1) rates of consideration for liver transplantation, and (2) completion of serious illness discussions. Findings will inform adaptations to the intervention and facilitators for its dissemination.
CONDITIONS
Official Title
Veteran-Centered Care for Advanced Liver Disease (Vet-CALD)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients will be between 18 and 80 years of age
- Patients must be Veterans
- Patients must have been in care at one of the recruiting sites with 1 or more encounters in primary care or GI/Hepatology in the last 24 months
- Patients must have advanced liver disease, defined by ICD-10 codes for cirrhosis complications (ever) or MELD 3.0 >12 or MELD-Na >12 or Fibroscan LSM >20kpa
You will not qualify if you...
- Non-Veteran patients
- Patients who do not speak English, do not have access to a telephone or computers, or who are unable to complete a valid informed consent form after three attempts
- Patients who have already made significant progress toward study endpoints: prior liver transplantation, being on the transplant waiting list, or formal liver transplant evaluation in the past 3 years
- Patients with very limited life expectancy such as advanced cancer, acute-on-chronic liver failure, or hospice patients
- Patients hospitalized, or in long term care facilities or nursing homes at the time they meet inclusion criteria
- Patients with uncontrolled mental health conditions or schizophrenia documented in their medical chart
AI-Screening
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Trial Site Locations
Total: 8 locations
1
Central Arkansas Veterans Healthcare System , Little Rock, AR
Little Rock, Arkansas, United States, 72205
Actively Recruiting
2
VA Long Beach Healthcare System, Long Beach, CA
Long Beach, California, United States, 90822
Not Yet Recruiting
3
VA Palo Alto Health Care System, Palo Alto, CA
Palo Alto, California, United States, 94304-1207
Actively Recruiting
4
VA Greater Los Angeles Healthcare System, West Los Angeles, CA
West Los Angeles, California, United States, 90073-1003
Actively Recruiting
5
VA Connecticut Healthcare System West Haven Campus, West Haven, CT
West Haven, Connecticut, United States, 06516-2770
Not Yet Recruiting
6
Miami VA Healthcare System, Miami, FL
Miami, Florida, United States, 33125
Not Yet Recruiting
7
VA North Texas Health Care System Dallas VA Medical Center, Dallas, TX
Dallas, Texas, United States, 75216-7167
Not Yet Recruiting
8
Michael E. DeBakey VA Medical Center, Houston, TX
Houston, Texas, United States, 77030-4211
Actively Recruiting
Research Team
J
Juana Campos, MA
CONTACT
F
Fasiha Kanwal, MD MSHS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
HEALTH_SERVICES_RESEARCH
Number of Arms
2
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