Accelerated Versus Routine Intermittent Theta Burst Stimulation iTBS Treatment for Depression Using Transcranial Magnetic Stimulation

What this Trial Is About

Researchers are evaluating two different protocols of intermittent theta burst stimulation iTBS, a type of repetitive transcranial magnetic stimulation, for treating depression. The study compares an accelerated iTBS protocol delivering 1200 pulses per session twice daily over 15 days with a routine protocol delivering 600 pulses once daily over 30 days. The goal is to assess which approach better affects depression symptoms over time in patients diagnosed with depression. Participants will receive iTBS treatment applied over the left dorsolateral prefrontal cortex using a MagPro R30 stimulator and a cool-B65 coil. The accelerated group will have two 6-minute 40-second sessions daily with a 50-minute break, while the routine group will have one 3-minute 20-second session daily. Both groups treatments follow precise protocols regarding pulse frequency, duration, and coil positioning. During the study, patients will be assessed by psychiatrists before treatment and again at 3 and 6 weeks after starting iTBS. They will also complete self-rated questionnaires weekly for 6 weeks and at 6 months post-treatment. Researchers will measure changes in depression rating scales such as MADRS-S, QIDS-SR, SDS, EQ-VAS, and CGI scores as primary and secondary outcomes. The total study duration for participants extends from the start of treatment through 6 months of follow-up for ongoing symptom monitoring.

VGR Accelerated TMS Treatment for Depression