Actively Recruiting

Phase Not Applicable
Age: 18Years - 65Years
All Genders
NCT06211400

Vibration Exercise for Crohn's to Observe Response

Led by University of Hertfordshire · Updated on 2025-07-18

168

Participants Needed

1

Research Sites

143 weeks

Total Duration

On this page

Sponsors

U

University of Hertfordshire

Lead Sponsor

U

University of Central Lancashire

Collaborating Sponsor

AI-Summary

What this Trial Is About

Background: Crohn's disease (CD) is a long-term inflammatory condition of the digestive system. People with CD often have unpredictable and debilitating symptoms, including abdominal pain, diarrhoea and fatigue. In addition, they require long-term treatment with frequent negative effects and often need surgery and hospitalisations. Therefore, people with CD report a lower health-related quality of life (HRQOL) compared with other people. Doctors are constantly trying to find new treatments to improve HRQOL and control symptoms and whole body vibration exercise could be a potential treatment. Exercise might be a simple, safe, and low-cost intervention for improving HRQOL in people with CD. This is because it has the potential to improve several aspects of physical, mental and social well-being simultaneously. Adults with CD have been shown to be less active than the general population and do not meet the recommended daily physical activity guidelines. One barrier to exercise is lack of time, however whole-body vibration exercise (where you stand and squat on a vibrating plate) can be done over a much shorter duration and at a lower intensity to gain potentially similar or at times greater benefits. More research is needed to understand the effects, both positive and negative of vibration exercise in people with CD. Aim: This study begins to understand whether undertaking a supervised 6-week vibration exercise programme for adults with mild to moderately active Crohn's disease improves HRQoL and other symptoms such as fatigue.

CONDITIONS

Official Title

Vibration Exercise for Crohn's to Observe Response

Who Can Participate

Age: 18Years - 65Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Aged over 18 to 65 years old
  • Clinical diagnosis of Crohn's disease for at least 4 weeks before randomization
  • Mild to moderate active Crohn's disease (CDAI 150-220)
  • Stable medication for at least 4 weeks before randomization
  • Able to provide written consent, complete study questionnaires, and travel to the research center for visits and exercise sessions
  • Doing less than 60 minutes of purposeful exercise per week
Not Eligible

You will not qualify if you...

  • Over 65 years old
  • Severe or uncontrolled medical conditions making participation undesirable
  • Serious autoimmune diseases like rheumatoid arthritis or systemic sclerosis
  • Planned major surgery within 3 months after randomization
  • Pregnant or planning pregnancy within 3 months after randomization
  • Poor tolerability to blood sampling or lack of venous access
  • Currently doing more than 60 minutes per week of purposeful exercise such as jogging or cycling
  • Participation in another clinical trial where concurrent participation is inappropriate
  • Any orthopedic implants (hip, knee, spine)

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

University of Hertfordshire

Hatfield, UK, United Kingdom, AL10 9EU

Actively Recruiting

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Research Team

L

Lindsay Bottoms

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

DOUBLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

OTHER

Number of Arms

2

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Vibration Exercise for Crohn's to Observe Response | DecenTrialz