Actively Recruiting
Video-oculography and Parkinson's Disease: A Prospective Study
Led by Association de Recherche Bibliographique pour les Neurosciences · Updated on 2025-10-01
30
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
A
Association de Recherche Bibliographique pour les Neurosciences
Lead Sponsor
C
Centre Hospitalier Princesse Grace
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are studying patients with mild to moderate idiopathic Parkinson's disease to understand changes in eye movement markers over time. The study aims to explore how eye movement relates to neurological and cognitive evaluations across a 7-year follow-up. It also looks at how Parkinson's medications may affect these eye movement assessments and whether these evaluations can serve as markers for disease progression. Participants will undergo annual evaluations including medical history review, clinical, neurological, and neuropsychological assessments. They will have video-oculography examinations to measure eye movements, alongside routine care tests such as brain MRI, DaTScan, PET/CT scans, and MIBG myocardial scintigraphy. This follow-up continues yearly for 7 years to track progression and treatment effects. During the study, participants will have regular neurological and cognitive tests, brain imaging at baseline, year 3, and year 7, and detailed eye movement recordings. Researchers will measure changes in eye movement speed, latency, and accuracy, as well as cognitive and motor function scores. The study also monitors treatment changes and their impact on eye movement measures, with safety observations throughout the 7-year period.
CONDITIONS
Brief Title
Video-oculography and Parkinson's Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female adults
- Clinically defined idiopathic Parkinson's Disease
- Brain MRI performed within 12 months before inclusion
- Cerebral DaTSCAN or PET with F-DOPA confirming presynaptic dopaminergic denervation
- Hoehn & Yahr score between 1 and 3
- Normal clinical eye movement exam (minor smooth pursuit impairment allowed)
- No or minor neuro-cognitive disorders according to DSM5
- Ability to read and speak French
- Covered by a health insurance system
- Written informed consent signed
- Presence of a caregiver
You will not qualify if you...
- Psychiatric disorders except anxiety or mild to moderate depression
- Significant neurological comorbidities
- Brain MRI showing significant cerebrovascular disease beyond Fazekas I or other brain diseases including stroke
- Major cognitive impairment
- Signs or symptoms suggesting other degenerative extrapyramidal diseases such as cerebellar syndrome, vertical eye movement disorders, symmetrical parkinsonism, early dystonia, behavioral variant frontotemporal dementia, progressive aphasia or apraxia, severe postural instability or early falls, early bulbar dysfunction, ventilatory dysfunction, severe dysautonomia, DOPA-resistance, or neuroleptic use
- Normal MIBG myocardial scintigraphy if performed
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 7 years
Participants undergo yearly evaluations including medical history review, clinical, neurological and neuropsychological assessments, video-oculography examination, and inventories of routine care examinations such as brain MRI, cerebral DaTScan, PET/CT scans, MIBG myocardial scintigraphy, and blood tests.
Annual visits for 7 years
Trial Site Locations
Total: 1 location
1
Centre Mémoire / Centre de Gérontologie Clinique Rainier III / Princess Grace Hospital
Monaco, Monaco, 98000
Actively Recruiting
Research Team
S
Solange HESSE
K
Kévin POLET
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
OTHER
Number of Arms
1
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