Actively Recruiting
VIGOR: Virtual Genome Center for Infant Health
Led by Boston Children's Hospital · Updated on 2026-02-03
750
Participants Needed
10
Research Sites
257 weeks
Total Duration
On this page
Sponsors
B
Boston Children's Hospital
Lead Sponsor
B
Boston Medical Center
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study will provide rigorous evaluation of implementing a virtual genome center into community clinical settings without highly specialized resources, thereby offering generalizable insights as to how best to implement genomic medicine at scale and for other age groups. This intervention has great potential to address disparities in genomic medicine among low-income and underrepresented minority (URM) populations and will enhance capacity for providers and health systems to utilize highly specialized genomic techniques in their communities. The goal of this study is to achieve equitable access to state-of-the-art genomic medical care to sick newborns in community centers that predominately care for low-income and racial/ethnic minority populations through the creation of a virtual genome center (VIGOR). VIGOR will provide a venue for physician and family education, genomic expert consultation, reanalysis of unsolved sequencing data, and access to cutting edge therapeutic innovation, thereby facilitating institutionalization of genomic best practices in community settings, and not just highly specialized referral centers.
CONDITIONS
Official Title
VIGOR: Virtual Genome Center for Infant Health
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Newborns admitted to NICU with probable genetic conditions such as unexplained hypotonia, seizures, metabolic disorders, sex development disorders, interstitial lung disease, immunodeficiency, or multiple congenital anomalies
- At least one biological parent must be available to consent and participate
- Inclusion is based entirely on the baby's symptoms and clinical features, not on demographics
You will not qualify if you...
- A likely non-genetic cause for the baby's symptoms (e.g., birth injury from uterine rupture or placental problems)
- Clear clinical signs of known chromosomal disorders like trisomy 21 (Down syndrome)
- Conditions with known low genetic diagnostic yield such as VATER/VACTERL association or OEIS complex
- Infants who pass away before enrollment
- Known family history of genetic disease likely causing the baby's illness
- Babies with a prenatal genetic diagnosis
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 10 locations
1
USA Children's and Women's Hospital
Mobile, Alabama, United States, 36604
Actively Recruiting
2
Holtz Children's Hospital at Jackson Memorial Medical Center
Miami, Florida, United States, 33136
Actively Recruiting
3
Boston Medical Center
Boston, Massachusetts, United States, 02118
Actively Recruiting
4
Baystate Medical Center
Springfield, Massachusetts, United States, 01199
Actively Recruiting
5
UMass Memorial Hospital
Worcester, Massachusetts, United States, 01605
Actively Recruiting
6
Cooper University Hospital
Camden, New Jersey, United States, 08103
Actively Recruiting
7
Driscoll Children's Hospital Rio Grande Valley
Edinburg, Texas, United States, 78539
Actively Recruiting
8
The Women's Hospital at Renaissance
Edinburg, Texas, United States, 78539
Actively Recruiting
9
The Hospitals of Providence
El Paso, Texas, United States, 79938
Actively Recruiting
10
University of Texas Medical Branch
Galveston, Texas, United States, 77555
Actively Recruiting
Research Team
T
Timothy Yu, MD, PhD
CONTACT
V
Vanessa J Young, MS, BA, RN
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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