Actively Recruiting
Virtual Biopsy of Prostate Cancer Using PSMA PET and AI
Led by University Hospital of North Norway · Updated on 2025-12-05
220
Participants Needed
1
Research Sites
182 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Prostate cancer is the most common type of cancer in Norwegian men, but many tumors are slow-growing and do not require treatment. Today, MRI is good at detecting suspicious lesions, yet it cannot reliably distinguish aggressive tumors from low-grade ones. As a result, many men undergo repeated invasive biopsies. New PET tracers targeting PSMA improve tumor localization and may correlate with cancer aggressiveness, offering potential for better assessment. This project aims to develop a method to predict Gleason Score non-invasively by applying machine learning to PET and MRI data. The work involves early static and dynamic PSMA PET imaging, tracer kinetic modelling, deep learning, and validation of PET-based measurements of PSMA internalization using ex-vivo cellular methods. If successful, the project could reduce the number of biopsies, improve diagnostic accuracy, offer full 3D assessment of the prostate, shorten clinical workflows, and help identify patients who would benefit most from PSMA-based radioligand therapy.
CONDITIONS
Official Title
Virtual Biopsy of Prostate Cancer Using PSMA PET and AI
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients referred to clinical PET examination who have undergone prostate biopsies prior to PET
- Patients referred to a urologist for suspected prostate cancer based on clinical symptoms or elevated PSA levels who have not had biopsies prior to PET
You will not qualify if you...
- Previous prostatectomy
- Body weight under 100 kg
- MRI incompatible implants or other MRI incompatibilities
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Universitetssykehuset Nord Norge, Tromsø
Tromsø, Troms, Norway, 9019
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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