Actively Recruiting
Virtual Home-based Exercise Intervention (RISE) to Improve Cancer-Related Cognitive Impairment and Gut Microbiome in Adolescent and Young Adult Brain Tumor Survivors
Led by Emory University · Updated on 2026-01-09
60
Participants Needed
2
Research Sites
128 weeks
Total Duration
On this page
Sponsors
E
Emory University
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This clinical trial evaluates the impact of a research intervention of virtually supervised exercise program (RISE) on cancer-related cognitive impairment (CRCI), physical activity in adolescent and young adult (AYA) brain tumor survivors. This clinical trial also evaluates the impact of RISE on the collection of microorganisms that exist in the intestines (gut microbiome). Up to 45% of AYA brain tumor survivors experience CRCI, including issues with attention and memory. CRCI can have a negative impact on education, independent living and can worsen long-term quality of life. Moderate-intensity levels of exercise, particularly aerobic and resistance training, have been shown to improve cognitive function. Additionally, exercise can change the composition and function of the gut microbiome, which may lead to improved cognitive function. Unfortunately, only about 50% of AYAs with cancer receive exercise information or meet the physical activity recommendations. Tailoring a virtually delivered exercise intervention to meet the unique needs of AYAs may improve access to exercise. Participating in the virtual home-based exercise intervention, RISE, may improve physical activity and cognitive impairment in AYA brain tumor survivors and may also help researchers understand the relationship of exercise on the gut microbiome and cognitive function.
CONDITIONS
Official Title
Virtual Home-based Exercise Intervention (RISE) to Improve Cancer-Related Cognitive Impairment and Gut Microbiome in Adolescent and Young Adult Brain Tumor Survivors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 15 to 39 years
- Diagnosed with primary brain tumor and received cranial radiotherapy
- Between 6 months and 4 years after cranial radiotherapy
- Functional Assessment of Cancer Therapy (FACT)-Cognitive Function score less than 60 based on self-report
- Able to provide informed consent or assent
- Able to walk and cleared by a healthcare provider to participate based on the Physical Activity Readiness Questionnaire
- Currently doing less than 150 minutes of physical activity per week
- Willing to use smartphone-based applications
You will not qualify if you...
- Secondary cancers, germline genetic syndromes, or recurrent brain tumor disease requiring re-irradiation
- Moderate to severe traumatic brain injury with brain damage beyond what is expected from tumor and treatment
- Developmental disorders such as autism or major psychotic illnesses like schizophrenia or depression to avoid confounding effects
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Emory University Hospital
Atlanta, Georgia, United States, 30322
Actively Recruiting
2
MD Anderson Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
Research Team
J
Jinbing Bai, PhD, RN
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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