Actively Recruiting
Virtual Reality for ICU Delirium Prevention
Led by Cedars-Sinai Medical Center · Updated on 2026-03-17
822
Participants Needed
1
Research Sites
107 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to evaluate whether daily exposure to immersive virtual reality (VR) can reduce the incidence of delirium in high-risk, non-intubated ICU patients. Participants will be randomized to either standard ICU care or standard care plus once-daily 15-minute VR sessions consisting of calming natural scenes, guided meditation, and music. The study population includes adult surgical ICU patients at Cedars-Sinai who are CAM-ICU negative at enrollment and possess at least one established risk factor for delirium. Outcomes will include the incidence and duration of delirium, ICU and hospital length of stay, feasibility of the VR intervention, and the frequency of adverse events. By targeting a high-risk population with an innovative non-pharmacologic therapy, this trial aims to generate data to support integration of VR into ICU delirium prevention protocols.
CONDITIONS
Official Title
Virtual Reality for ICU Delirium Prevention
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Currently admitted to the surgical ICU at Cedars-Sinai Medical Center
- Expected ICU stay longer than 48 hours
- Richmond Agitation Sedation Scale (RASS) score between -1 and +2
- Negative CAM-ICU (no delirium) at enrollment
- At least one risk factor for delirium including age 65 or older, history of cognitive impairment, sepsis, SOFA score greater than 5, history of alcohol or benzodiazepine abuse, or recent major surgery
You will not qualify if you...
- Unwilling or unable to participate
- Intubated or have a tracheostomy
- History of severe motion sickness
- Unable to follow commands (e.g., severe aphasia, deafness, Glasgow Coma Scale less than 13)
- Facial or head deformity preventing use of VR headset
- Need for corrective lenses stronger than -2.5 diopters that cannot be corrected with contact lenses
- Seizure within the past year
- Unable to understand instructions or provide consent
- Pregnant
- Hemodynamic instability (mean arterial pressure less than 65 despite support)
- Receiving end-of-life care
- Severe agitation or current delirium (positive CAM-ICU screen)
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Cedars Sinai Medical Center
Los Angeles, California, United States, 90048
Actively Recruiting
Research Team
D
Devon S Callahan, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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