Actively Recruiting
Virtual Reality for ICU Delirium Prevention in Surgical ICU Patients
Led by Cedars-Sinai Medical Center · Updated on 2026-03-17
822
Participants Needed
1
Research Sites
11 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating whether daily exposure to immersive virtual reality (VR) can reduce the occurrence of delirium in high-risk, non-intubated adult patients in the surgical intensive care unit (ICU). This study focuses on patients who are CAM-ICU negative at enrollment and have at least one known risk factor for delirium, such as advanced age, cognitive impairment history, sepsis, or recent major surgery. The goal is to explore a non-drug approach to help prevent delirium in the ICU setting. Participants will be randomly assigned to receive either standard ICU care alone or standard care plus daily 15-minute VR sessions for up to five days. These VR sessions feature calming natural scenes, guided meditation, and music, delivered through a head-mounted device. The study assesses the feasibility of using this VR intervention alongside usual delirium prevention measures. During the study, participants will be monitored daily for delirium using the CAM-ICU assessment, with evaluations in the morning and evening throughout their ICU stay, for up to 24 months after enrollment. Researchers will also track the duration of delirium, length of ICU and hospital stays, patient acceptance of VR sessions, and any adverse events such as nausea or dizziness. Participation involves regular assessments and safety monitoring until hospital discharge or completion of VR sessions.
CONDITIONS
Brief Title
Virtual Reality for ICU Delirium Prevention
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Individuals currently admitted to the surgical ICU at Cedars-Sinai Medical Center
- Expected ICU stay longer than 48 hours
- Richmond Agitation Sedation Scale (RASS) score between -1 to +2
- CAM-ICU negative at enrollment
- Have at least one risk factor for delirium such as age 65 or older, history of cognitive impairment, sepsis, SOFA score over 5, history of alcohol or benzodiazepine abuse, or recent major surgery
You will not qualify if you...
- Unwilling or unable to participate
- Intubated or have tracheostomy
- History of severe motion sickness
- Unable to follow commands (e.g., severe aphasia, deafness, Glasgow Coma Scale under 13)
- Facial or head deformity preventing use of VR headset
- Require corrective lenses stronger than -2.5 that cannot be corrected with contact lenses
- Had a seizure in the past year
- Unable to understand instructions or consent
- Pregnant
- Hemodynamic instability (mean arterial pressure under 65 despite support)
- Receiving end-of-life care
- Severe agitation or delirium (positive CAM-ICU screen)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 5 days
Participants receive daily virtual reality sessions for up to 5 days in addition to regular delirium prevention measures in the ICU.
Daily sessions during ICU stay for up to 5 days
Duration - Up to 24 months
Participants are monitored for incidence and duration of ICU delirium, length of ICU and hospital stay, and adverse events related to VR until ICU or hospital discharge, up to 24 months from enrollment.
Assessments during ICU admission and hospital stay up to 24 months
Trial Site Locations
Total: 1 location
1
Cedars Sinai Medical Center
Los Angeles, California, United States, 90048
Actively Recruiting
Research Team
D
Devon S Callahan, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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