Virtual Reality Mindfulness Intervention to Reduce Aggression in Adults with Schizophrenia or Schizoaffective Disorder

What this Trial Is About

Researchers are evaluating whether a virtual reality-based mindfulness intervention can reduce impulsive aggression in individuals diagnosed with schizophrenia or schizoaffective disorder. The study aims to understand if mindfulness delivered through VR improves emotion regulation and activates the dorsomedial prefrontal cortex dmPFC, a brain area involved in controlling emotions. The trial also investigates whether the effects of this intervention relate to the dose received. Participants are randomly assigned to receive one of two doses of the mindfulness VR intervention 16 or 24 sessions or a non-immersive distraction control. The mindfulness sessions use the TRIPP VR platform with immersive, dynamic environments and guided exercises led by a virtual instructor. Distraction activities include listening to music, viewing images, or watching videos for a similar duration over six weeks. Brain activity is measured with functional MRI during an emotion regulation task at baseline, after 16 sessions, and after 24 sessions. Participants undergo clinical assessments at multiple points, including measures of aggression, impulsivity, mood, anxiety, quality of life, and mindfulness. Safety monitoring includes evaluating simulator sickness and suicide risk. The study collects behavioral data on aggression and medication use, and all assessments are repeated during the study to monitor changes. Participants continue their regular psychiatric care throughout the trial, which lasts approximately six weeks of intervention plus assessment periods.

A Virtual Reality Mindfulness Application for Aggression in Schizophrenia