Actively Recruiting
Virtual Reality Mobility Assessment of Functional Vision in Retinal Disease
Led by National Eye Institute (NEI) · Updated on 2026-03-31
165
Participants Needed
2
Research Sites
388 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Background: The retina is a thin layer of tissue at the back of the eye. Retinal disease usually reduces a person s mobility because it affects how he or she moves through familiar and unfamiliar environments. Researchers want to see if a virtual reality (VR) tool can provide an easier and more accurate way to assess mobility. Objective: To learn if researchers can track changes in mobility in people with retinal disease using a new VR tool. Eligibility: People aged 5 and older with retinal disease that affects their vision, and healthy volunteers. Design: Participants will have 2-3 clinic visits. Participants will wear goggles or sit in front of a screen while sitting. Using a game controller, they will navigate through 4 obstacle courses presented in VR. Participants will have a medical history exam. They will answer questions about their family history. They will fill out questionnaires about the vision and mobility issues they have in their daily lives. Participants will have a complete eye exam. They will read letters from a chart. Their eye pressure will be measured. Their pupils may be dilated with eye drops. Pictures of their eye will be taken. Lights will be shined in their eyes. Participants will take a visual field test. For this, they will look into a dome and press a button when they see a light. Participants will have an electroretinogram. For this, they will sit in the dark with their eyes patched. Then their eyes will be numbed with eye drops and they will wear contact lenses while watching flashing lights. Participants will have optical coherence tomography. This is a noninvasive procedure. It produces cross-sectional pictures of the retina....
CONDITIONS
Official Title
Virtual Reality Mobility Assessment of Functional Vision in Retinal Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participant must be 5 years or older at the NEI site or 13 years or older at the USyd site
- Participant or legal guardian must understand and sign the informed consent document
- Participant must be able to cooperate with the testing required for this study
- Participant must be able to read and speak English
- If a minor, the parent or legal guardian must also be able to read and speak English
- Healthy volunteers must not have retinal disease in either eye
You will not qualify if you...
- Participant is currently in another investigational study and receiving study therapy
- Participant is unable to comply with study procedures
- Study eye of healthy volunteers must have visual acuity of 20/20 or better, with or without correction
- Study eye of participants with retinal disease must have retinal dysfunction or degeneration confirmed by clinical methods such as perimetry, ERG, or imaging
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
2
University of Sydney
Sydney, Australia
Actively Recruiting
Research Team
D
Daniel W Claus, R.N.
CONTACT
B
Brett G Jeffrey, Ph.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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