Virtual Reality Intervention for Post-Intensive Care Syndrome (PICS): A Pilot Randomized Controlled Trial Evaluating Cognitive, Physical, and Psychological Outcomes

What this Trial Is About

This trial investigates whether virtual reality (VR) helps improve thinking and memory skills in adults who have stayed in the intensive care unit (ICU). It focuses on patients who required a breathing machine or had a long ICU stay and are at risk of memory or brain fog problems. The study compares the effects of immersive VR, tablet-based brain games, and standard care on cognitive recovery after critical illness. Participants are randomly assigned to one of three groups: VR-based rehabilitation using a headset to play six brain-training games, tablet-based rehabilitation with the same games on a 2D device, or standard ICU care without digital cognitive training. Each digital therapy involves daily 12-minute sessions for up to seven days or until ICU discharge. The VR group uses a Meta Quest Pro device for immersive cognitive and motor exercises, while the tablet group uses a handheld device for the same tasks. During the study, participants complete memory and thinking tests at the start and about two weeks later. They also answer follow-up questions about their cognitive abilities for up to six months after hospital discharge. Safety is monitored continuously during therapy sessions, and researchers track outcomes like the Montreal Cognitive Assessment. Additional evaluations include muscle strength, post-trauma stress, quality of life, mood, anxiety, and any VR-related discomfort. The study lasts several months, with multiple follow-up visits to assess recovery.

Virtual Reality for Recovery After Intensive Care (PICS)