Actively Recruiting
Virtual Reality vs Traditional Cognitive Training in Patients With Severe Acquired Brain Injury
Led by Anna Estraneo · Updated on 2025-09-29
28
Participants Needed
3
Research Sites
109 weeks
Total Duration
On this page
Sponsors
A
Anna Estraneo
Lead Sponsor
I
Istituti Clinici Scientifici Maugeri SpA
Collaborating Sponsor
AI-Summary
What this Trial Is About
Considerable evidence exists for using Virtual Reality (VR) for rehabilitation of acquired brain injury (ABI), with a particular focus on stroke. However, to date very little evidence has been collected in patients with ABI with different aetiologies (i.e., traumatic or anoxic brain injury) and level of severity (i.e., severe, sABI). The present multicentre study aims to overcome current literature issues as heterogeneity of populations and outcomes, small sample sizes and a lack of randomized controlled trials, which can affect the level of evidence and generalizability of results, to determine the effectiveness of a non immersive VR-based rehabilitation versus traditional cognitive training (TCT).
CONDITIONS
Official Title
Virtual Reality vs Traditional Cognitive Training in Patients With Severe Acquired Brain Injury
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Level of Cognitive Functioning (LCF) 4 or higher at study entry
- Age between 18 and 75 years
- Stable clinical diagnosis with stable LCF
- Time since brain injury between 28 days and 6 months
- Ability to complete the pre-test A section of the Italian Trail Making Test
- Pathological B-A score of the Trail Making Test adjusted for age and education
- Signed informed consent by the patient or primary caregiver
You will not qualify if you...
- Severe medical conditions that prevent participation or affect diagnosis
- Previous neurodegenerative or acquired neurological diseases affecting cognition, such as dementia
AI-Screening
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Trial Site Locations
Total: 3 locations
1
Polo Specialistico Riabilitativo Fondazione Don Carlo Gnocchi ONLUS
Sant'Angelo dei Lombardi, Avellino, Italy, 83054
Actively Recruiting
2
ICS Maugeri
Telese Terme, Benevento, Italy, 82037
Actively Recruiting
3
IRCCS Santa Maria Nascente Fondazione Don Gnocchi ONLUS
Milan, Italy, 20148
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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