Actively Recruiting
A Pilot Study of Virtual Rehabilitation After Hematopoietic Cell Transplantation
Led by Emory University · Updated on 2025-09-19
40
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
E
Emory University
Lead Sponsor
I
Incyte Corporation
Collaborating Sponsor
AI-Summary
What this Trial Is About
Chronic graft-versus-host disease (cGVHD) is a common complication that affects patients after hematopoietic cell transplantation (HCT), impacting many organs and requiring long-term treatment that can reduce quality of life. Researchers are evaluating a virtual rehabilitation program designed for children and young adults aged 8 to 23 years who are at least 100 days post-HCT, including those with cGVHD, to see if it is feasible and if it can improve physical functioning and quality of life. This pilot study is led by Emory University and focuses on overcoming barriers to rehabilitation such as travel distance, infection risk, and limited pediatric expertise. The program involves participants receiving exercise equipment like dumbbells and resistance bands and engaging in twice-weekly, 30-minute one-on-one online sessions with pediatric physical therapists for 12 weeks. These sessions include aerobic and stretching exercises tailored to patient needs, including specific stretches for joints with limited range of motion. The rehabilitation is delivered through a telemedicine platform commonly used in the blood and marrow transplant clinic, and adherence is supported during monthly clinic visits. Participants will undergo assessments by a pediatric physical therapist at the start, end, and approximately three months after the program to evaluate physical function and quality of life improvements. The main outcomes measured are adherence to the program during the 12-week intervention and the program's feasibility over up to four years. Secondary measures include changes in a 6-minute walk test from baseline to the end of the program. The total participation involves regular virtual sessions and follow-up assessments to monitor progress and safety.
CONDITIONS
Brief Title
Virtual Rehabilitation in HCT
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Recipients between the ages of 8 and 23 years who are at least 100 days post allogeneic hematopoietic cell transplantation.
- Patients aged 8 to 14 years must have a caregiver willing to assist with exercises during sessions.
- Patients must have access to a device and reliable internet connection.
- Patients must be cleared for exercise by their physician.
- Eligibility is regardless of underlying diagnosis, preparative regimen, or graft source.
You will not qualify if you...
- Any physical condition preventing exercise as determined by the treating physician.
- Non-English-speaking patients due to lack of interpreter services on the telemedicine platform.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person or virtual) for eligibility assessment
Duration - 12 weeks
Participants take part in a virtual exercise and rehabilitation program focusing on aerobic and stretching exercises supervised by physical therapists.
Two 30-minute virtual sessions per week
Duration - Up to 4 years
Participants are monitored for adherence and feasibility of the rehabilitation program, with assessments continuing up to 4 years.
Monthly standard clinic visits for adherence encouragement and assessments
Trial Site Locations
Total: 1 location
1
Children's Healthcare of Atlanta
Atlanta, Georgia, United States, 30322
Actively Recruiting
Research Team
M
Muna Qayed, MD, MsCR
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
1
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