Actively Recruiting
Feasibility of a Virtually Delivered LASO-3 Diet Intervention for Chemotherapy-Induced Peripheral Neuropathy in Post-Treatment Cancer Survivors
Led by University of Michigan Rogel Cancer Center · Updated on 2026-03-03
50
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
U
University of Michigan Rogel Cancer Center
Lead Sponsor
H
Hope Foundation
Collaborating Sponsor
AI-Summary
What this Trial Is About
This clinical trial investigates whether a virtually delivered diet intervention called LASO-3 can help improve chemotherapy-induced peripheral neuropathy (CIPN) in cancer survivors after treatment. CIPN is nerve damage caused by chemotherapy that leads to numbness, tingling, or pain in the hands or feet, and currently, there are few treatments available. The LASO-3 diet focuses on reducing added sugar intake, increasing fiber, and boosting omega-3 fatty acids to reduce inflammation, which may contribute to CIPN. Participants are randomly assigned to one of two groups. One group receives virtual LASO-3 nutrition counseling sessions led by a Registered Dietitian over 12 weeks, starting with weekly 30-minute sessions for 4 weeks, followed by biweekly 15-minute sessions for 8 weeks. The other group attends eight virtual general health education sessions lasting 15 to 30 minutes over 12 weeks, and may receive intervention materials and up to four dietary counseling sessions after the study. Blood samples are collected from all participants throughout the trial. Participants complete patient-reported outcome measures at the start and after 12 weeks. Researchers track recruitment, session attendance, and self-reported adherence to the diet goals, as well as acceptability and satisfaction with the intervention. The trial lasts up to 24 weeks and involves regular virtual sessions, blood collections, and surveys to assess the impact of the diet on CIPN symptoms in post-treatment cancer survivors.
CONDITIONS
Brief Title
A Virtually Delivered Diet Intervention (LASO-3) for the Improvement of Chemotherapy-Induced Peripheral Neuropathy in Cancer Survivors Post-treatment
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 years or older
- At least three months since last receiving neurotoxic chemotherapy
- Self-report moderate numbness and tingling (score 2 or higher) in the last week
- Speak and read English
- Have access to the internet
You will not qualify if you...
- Pre-existing neuropathy from any cause
- Plan to start a new prescription of duloxetine during the study
- Enrolled in other symptom management trials affecting neuropathy
- Current inflammatory disease
- Routine use of NSAIDs or steroid supplements
- Eating three or more servings of fish per week or taking fish oil/flax oil supplements daily
- Eating less than five servings per week of sweets or sugar-sweetened beverages
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person or virtual)
Duration - 12 weeks
Participants attend virtual diet or health education sessions and undergo blood sample collection throughout the trial.
Weekly virtual LASO-3 nutrition counseling sessions for 4 weeks, then every 2 weeks for 8 weeks; or eight virtual general health education sessions over 12 weeks; blood sample collections occur during this period
Duration - Up to 12 weeks post-treatment
Participants may receive intervention materials and up to 4 dietary counseling sessions post-study.
Up to 4 dietary counseling sessions (virtual)
Trial Site Locations
Total: 1 location
1
University of Michigan Rogel Cancer Center
Ann Arbor, Michigan, United States, 48109
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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