Virtual LASO-3 Diet Program to Improve Nerve Symptoms After Chemotherapy in Cancer Survivors

What this Trial Is About

Researchers are evaluating a virtually delivered diet intervention called LASO-3 to improve chemotherapy-induced peripheral neuropathy CIPN in cancer survivors after treatment. CIPN causes nerve damage resulting in numbness, tingling, or pain in the hands or feet and currently has limited treatment options. The study focuses on dietary changes that may reduce inflammation, which contributes to CIPN symptoms, aiming to support cancer survivors recovery and quality of life. The LASO-3 intervention involves virtual nutrition education sessions led by a Registered Dietitian. The diet targets lowering added sugar to less than 10% of daily calories, increasing fiber intake to at least 20 grams daily, and boosting moderate to high omega-3 seafood consumption or plant-based omega-3 sources. Participants in the LASO-3 group receive weekly 30-minute counseling sessions for 4 weeks followed by biweekly 15-minute sessions for 8 weeks. The study also includes a comparison group receiving general health education sessions virtually over 12 weeks. Blood samples are collected from all participants throughout the trial. Participants complete patient-reported outcome questionnaires at baseline and 12 weeks to assess feasibility and adherence. Researchers measure recruitment success, session attendance, and self-reported diet adherence over 24 weeks. Satisfaction with the intervention is also evaluated at 12 weeks. The study aims to gather information on the practicality of delivering this diet program virtually and its potential to manage CIPN symptoms. The trial is expected to continue until March 2028.

A Virtually Delivered Diet Intervention (LASO-3) for the Improvement of Chemotherapy-Induced Peripheral Neuropathy in Cancer Survivors Post-treatment