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Vista Protein Expression of Monocyte and T Cell Subsets in Multiple Sclerosis and Its Clinical Correlation: A 1-Year Follow-up Study
Led by Koç University · Updated on 2025-09-03
60
Participants Needed
2
Research Sites
47 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating the expression of VISTA, a newly identified immune regulatory protein, in monocytes and T cells of patients diagnosed with Multiple Sclerosis (MS) and Clinically Isolated Syndrome (CIS) compared to healthy individuals. The study aims to understand the role of VISTA in MS and explore its potential as a biomarker and in developing new treatments. It will also examine how VISTA expression changes over time and its clinical relevance during a 1-year follow-up. The study involves 30 people with MS and 30 healthy controls. Blood samples will be collected at the time of the first MS attack and again at 6 and 12 months to measure VISTA protein secretion and immune cell function. Different immune cell subtypes, including CD4+, CD8+ T cells, monocytes, and T regulatory cells, will be stimulated to analyze their pro- and anti-inflammatory responses and compare them between MS patients and healthy controls. Participants will undergo blood sampling at baseline, 6 months, and 12 months for clinical and radiological assessments. Researchers will measure VISTA protein secretion and cytokine profiles to evaluate immune cell functions and correlate these findings with clinical outcomes. The study duration spans one year, during which participants will be monitored for changes in immune responses and disease progression to better understand MS pathophysiology.
CONDITIONS
Brief Title
Vista Protein Expression of Monocyte and T Cell Subsets in Multiple Sclerosis and Its Clinical Correlation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 18 years or older diagnosed with MS or CIS according to the 2017 McDonald criteria
- No diagnosis of any autoimmune disease or malignancy
- No new diagnosis of autoimmune disease or malignancy during the 1-year follow-up period
- No use of antibiotics, nonsteroidal anti-inflammatory drugs (NSAIDs), or steroid treatments within one month prior to blood sampling
- No vaccination within one month prior to blood sampling
- Not in the menstrual cycle at the time of blood sampling
You will not qualify if you...
- Age below 18 years
- Presence of a previous or newly diagnosed autoimmune disease or malignancy at the time of blood sampling
- Use of antibiotics, nonsteroidal anti-inflammatory drugs (NSAIDs), or steroid treatments within one month prior to blood sampling
- Vaccination within one month prior to blood sampling
- Being in the menstrual cycle at the time of blood sampling
- Patients without a definitive MS diagnosis according to the 2017 McDonald criteria will not be included in the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants undergo baseline assessments including blood sampling and clinical and radiological evaluations.
1 visit (in-person)
Duration - 12 months
Participants are followed for 1 year with clinical and radiological evaluations to assess disease progression and immune cell function.
2 visits (at Month 6 and Month 12)
Trial Site Locations
Total: 2 locations
1
Koc University
Istanbul, Istanbul, Turkey (Türkiye)
Actively Recruiting
2
Bakirkoy Prof. Dr. Mazhar Osman Training and Research Hospital for Psychiatric, Neurologic and Neurosurgical Diseases, University of Health Sciences, Istanbul, Turkey
Istanbul, Turkey (Türkiye)
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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