Actively Recruiting

Age: 6Months - 90Years
All Genders
ID04310241

Oculomotor Disorders: Experimental and Clinical Study of Visual Function in Amblyopia and Strabismus

Led by The Cleveland Clinic · Updated on 2026-03-04

150

Participants Needed

1

Research Sites

N/A

Total Duration

On this page

AI-Summary

What this Trial Is About

This research investigates visual function abnormalities in people with amblyopia and strabismus, conditions that affect vision clarity, contrast sensitivity, and binocular function. The study aims to measure these visual functions before, during, and after therapy to understand how treatment impacts them. The treatments being studied include glasses, patching, and atropine eye drops, along with strabismus surgery when needed. Participants will have various vision tests such as eye movement tracking, contrast sensitivity, grating and vernier acuity, visual acuity, binocular function, reading, and visual scanning evaluated. These tests will occur before therapy, during treatment, and after treatment ends. If strabismus surgery is performed, testing will continue afterward to observe changes. Throughout the study, participants will be assessed at multiple points using the visual function tests to monitor progress. The main outcomes focus on changes in visual functions over a period of up to three years, depending on treatment duration. The study is observational and follows participants from initial evaluation through the course of their therapy.

CONDITIONS

Brief Title

Visual Function Abnormalities in Strabismus and Amblyopia and Response to Therapy

Who Can Participate

Age: 6Months - 90Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • History of amblyopia or presence of amblyogenic risk factors
  • Participants aged between 6 months and 90 years
  • Both males and females are eligible
  • Ability to cooperate with vision testing procedures
Not Eligible

You will not qualify if you...

  • History of neurologic disorders

AI-Screening

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

Outpatient Treatment

Duration - Up to 3 years depending on duration of treatment

Participants undergo amblyopia therapy, which may include glasses, patching, and/or atropine eye drops. Visual function measurements are taken during this therapy period.

Visits scheduled during therapy to measure visual functions

Trial Site Locations

Total: 1 location

1

Cleveland Clinic

Cleveland, Ohio, United States, 44195

Actively Recruiting

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Research Team

K

Kimberly Baynes, MSN

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

2

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Published Research Related To This Trial

Contrast sensitivity in amblyopia: the fellow eye of untreated and successfully treated amblyopes.

Klio I Chatzistefanou, George P Theodossiadis, Alexandros G Damanakis...

https://pubmed.ncbi.nlm.nih.gov/16213398