Actively Recruiting
Visualization of Inspiratory Effort and Respiratory Mechanics to Promote Lung- and Diaphragm Protective Ventilation
Led by University Hospital, Antwerp · Updated on 2025-04-06
150
Participants Needed
3
Research Sites
166 weeks
Total Duration
On this page
Sponsors
U
University Hospital, Antwerp
Lead Sponsor
R
Research Foundation Flanders
Collaborating Sponsor
AI-Summary
What this Trial Is About
This is a multicentre prospective cohort trial in adult and pediatric ICU patients. The investigators will measure the effect of a patient's inspiratory effort during mechanical ventilation on the lungs and diaphragm. The investigators will daily (for a maximum of 8 days) measure esophageal pressures with a balloon catheter to quantify inspiratory effort and respiratory muscle function, and perform daily ultrasound measurements of the diaphragm and the lungs. The investigators hypothesize that a small inspiratory effort will result in the preservation of diaphragm function and have no adverse effect on lung function.
CONDITIONS
Official Title
Visualization of Inspiratory Effort and Respiratory Mechanics to Promote Lung- and Diaphragm Protective Ventilation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age greater than 28 days
- Weight greater than 3 kilograms
- Requires invasive mechanical ventilation
- Expected to need mechanical ventilation for more than 48 hours
You will not qualify if you...
- Refusal of consent
- Mechanical ventilation within 2 weeks before enrollment
- Known anatomical malformation of the diaphragm, including congenital diaphragmatic hernia
- Contraindication to placement of a nasogastric esophageal balloon catheter
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
Antwerp University Hospital (UZA)
Edegem, Antwerp, Belgium, 2650
Actively Recruiting
2
University Hospital Leuven (UZL)
Leuven, Belgium, 3000
Actively Recruiting
3
The Hospital for Sick Children (SickKids)
Toronto, Ontario, Canada, M5G 1X8
Actively Recruiting
Research Team
V
Vertongen
CONTACT
M
Marquez
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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