Actively Recruiting
Visualization of Neural Targets With 3T MRI
Led by University Health Network, Toronto · Updated on 2024-05-08
40
Participants Needed
1
Research Sites
204 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Functional neurosurgery is dedicated to modulating aberrant neural circuits associated with a wide range of neurological conditions. Recently, technological advances in MRI have permitted marked improvements in the direct visualization of neural targets, which is necessary for the accurate targeting in functional neurosurgery procedures. This research study focuses on imaging patient brains before their scheduled procedures by using a 3 tesla (T) MRI to provide higher resolution and quality brain images. The reason for this study is to assess the image quality using different MRI sequences or settings to improve the image resolution of the most common functional neurosurgery targets (e.g., subthalamic nucleus, globus pallidus, and thalamus) and compare the image quality of the brains in patients with healthy controls. Performing a preoperative MRI is standard-of-care for patients indicated for deep brain stimulation (DBS), gamma knife radiosurgery (GKRS), radiofrequency ablation (RFA), magnetic resonance-guided focused ultrasound (MRgFUS). MRI sequence parameters shown to improve the image quality of different neural structures in a recent literature review (Boutet et al. 2021) will be reproduced on the 3T MRI at Toronto Western Hospital.
CONDITIONS
Official Title
Visualization of Neural Targets With 3T MRI
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 85 years
- Preparing to undergo a functional neurosurgical intervention (e.g., DBS, RFA, GKR, or MRgFUS) at Toronto Western Hospital (not applicable for healthy volunteers)
- Able to understand the purpose of this research and willing to sign the informed consent form
- Understand that the research aims to enhance knowledge of brain functioning and that there will be no direct or indirect benefit from participation
You will not qualify if you...
- Contraindication for MRI (e.g., implanted cardiac device, metal in eyes, aneurysm clip)
- Serious cognitive or psychological impairments preventing informed consent
- Unable to communicate effectively or efficiently (e.g., speech deficits such as dysarthria or aphasia, or non-English speaking)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Toronto Western Hospital
Toronto, Ontario, Canada, M5T 2S8
Actively Recruiting
Research Team
T
Tasnuva T Hoque, BSc
CONTACT
M
Monika Singh
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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