Actively Recruiting
Does Vitamin C Increase the Body Heat Generated By The Nervous System?
Led by Colorado State University · Updated on 2026-01-14
20
Participants Needed
1
Research Sites
90 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goals of this clinical trial are to determine whether or not vitamin C is able to: (1) increase the body heat generated by the sympathetic nervous system; and, (2) increase circulating vitamin D concentration during sympathetic nervous system stimulation in adult humans aged 18-40 years who meet the criteria for overweight based on body mass index. The main question it aims to answer are: 1. By how much does body temperature increase during stimulation of beta-adrenergic receptors when vitamin C is given. 2. By how much does circulating vitamin D concentration increase during stimulation of beta-adrenergic receptors when vitamin C is given. Participants will will be asked to: * undergo measures of body temperature * have blood sampled on two separate occasions: once during stimulation of beta adrenergic receptors, and once during stimulation of beta-adrenergic receptors while also been given vitamin C.
CONDITIONS
Official Title
Does Vitamin C Increase the Body Heat Generated By The Nervous System?
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18-40 years (inclusive)
- Body mass index greater than or equal to 25 kg/m2 and less than 30 kg/m2
- Weight stable (no change in body mass greater than 5 lbs within the previous 6 months)
- Willing to abstain from caffeine and alcohol for 24 hours prior to two different study visits
- Competent in English to understand the informed consent and communicate clearly during the study
You will not qualify if you...
- History of autonomic, cardio-pulmonary, or metabolic disease such as heart failure, hypertension, arrhythmia, vascular disease, or diabetes
- Pregnancy or breastfeeding
- Habitual use of tobacco, nicotine products, or recreational drugs (2 or more uses within the previous month)
- History of sulfite allergy
- Taken vitamin or antioxidant supplements in the previous 4 weeks (e.g., Vitamin C, Vitamin E, multivitamins)
AI-Screening
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Trial Site Locations
Total: 1 location
1
Colorado State University
Fort Collins, Colorado, United States, 80523
Actively Recruiting
Research Team
C
Christopher Bell, PhD
CONTACT
T
Taylor Ewell, M.S.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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