What is vitamin C studying for metabolism changes and vitamin D?

Researchers are studying whether vitamin C can increase body heat produced by the nervous system and raise vitamin D levels during nervous system activation. The trial evaluates changes in body temperature and vitamin D concentration during stimulation of beta-adrenergic receptors with and without vitamin C. This research is led by Colorado State University.

Who may be eligible for this metabolism changes and vitamin D clinical trial?

Adults aged 18 to 40 years with a body mass index between 25 and 30 kg/m2 may be eligible. Participants must have stable weight, be willing to avoid caffeine and alcohol before visits, and be competent in English. People with certain heart, lung, or metabolic diseases or recent vitamin supplement use may be excluded. Please review eligibility criteria for more details.

Is there any cost to participate in this metabolism changes and vitamin D clinical trial?

Study-related care, including the study procedure and all trial visits, is provided at no cost. Personal travel expenses may vary and are not guaranteed to be covered. Participants can plan accordingly for their visit costs.

Actively Recruiting

Phase Not Applicable

Age: 18Years - 40Years

All Genders

Healthy Volunteers

ID07341308

Does Vitamin C Increase the Body Heat Generated By The Nervous System?

Led by Colorado State University · Updated on 2026-01-14

Participants Needed

Research Sites

26 weeks

Total Duration

AI-Summary

What this Trial Is About

This trial studies adults aged 18 to 40 years with a body mass index indicating overweight to see if vitamin C can increase the heat produced by the sympathetic nervous system and raise vitamin D levels during nervous system activation. It aims to find out how much body temperature and circulating vitamin D change when beta-adrenergic receptors are stimulated with and without vitamin C. Participants visit the lab twice where beta-adrenergic receptors are stimulated using isoproterenol. One visit includes isoproterenol with saline only, and the other includes isoproterenol with saline and vitamin C. The order of these visits is randomized. Body temperature is measured with a thermometer and thermal camera, and blood samples are taken to measure vitamin D levels. During the study, participants undergo body temperature measurements and blood draws at baseline and after doses of isoproterenol at 30, 60, and 90 minutes. Researchers monitor changes in temperature and vitamin D concentration to assess the effect of vitamin C during stimulation. The total participation involves two lab visits with these assessments and monitoring under medical supervision.