Actively Recruiting
Vitamin D for Critically Traumatic Patients
Led by National Taiwan University Hospital · Updated on 2024-08-16
100
Participants Needed
1
Research Sites
426 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Trauma has been an important global public health issue. Yet it is the sixth cause of death in Taiwan, trauma brings great negative impact to national productivity since it presents specifically as the leading cause of death for the population aged below 40 years. According to the national databank from Formosa Association for the Surgery of Trauma, mortality rate in critically traumatic patients with injury severity score (ISS) ≥ 25 is as high as 23%. Vitamin D, a pleiotropic hormone, regulates directly functions of most organs and immune system. It has been proven that vitamin D insufficiency or deficiency would deteriorate survival of critically ill patients, while supplementation of high-dose vitamin D ameliorates the clinical outcomes. This study investigates whether multiple high doses of vitamin D supplementation in one week can decrease the mortality and morbidity in critically traumatic patients. The serum levels of calcidiol and PTH will be measured on Day 0, Day 3, Day 10, Day 15, Day 30 and Day 60 before and after vitamin D supplementation.
CONDITIONS
Official Title
Vitamin D for Critically Traumatic Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults over 20 years old with major trauma
- Injury Severity Score of 9 or higher
- Admitted to the Intensive Care Unit (ICU)
You will not qualify if you...
- Chronic liver disease
- Unable to receive enteral feeding
- Hypercalcemia
- Currently using vitamin D, estrogen, or bone disease medications
- High risk of hypercalcemia from conditions like metastatic cancer, primary hyperparathyroidism, sarcoidosis, or multiple myeloma
AI-Screening
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Trial Site Locations
Total: 1 location
1
National Taiwan University Hospital
Taipei, Taiwan
Actively Recruiting
Research Team
Y
Yin-Yi Han, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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