Actively Recruiting
Vitamin D and Its Metabolites Quantification in Adipose Tissues of Obese and Non-obese Patients.
Led by Assistance Publique Hopitaux De Marseille · Updated on 2023-07-27
60
Participants Needed
1
Research Sites
495 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Vitamin D (VD) is a pleiotropic hormone, involved in many physiological processes including calcium and phosphorus absorption. The VD metabolism begin to be well-known and involves a hepatic hydroxylation (mediated by enzymes, which belong to the cytochrome P450 family) leading to the production of the 25(OH)D, which corresponds to the circulating form of the VD. After circulation in blood, the 25(OH)D is submitted to a second hydroxylation in the kidney resulting to the generation of 1,25(OH)2D, the active metabolite of VD. Numerous epidemiological studies reported an inverse relationship between obesity and circulation level of 25(OH)D. Several mechanisms could explain the low level of 25(OH)D observed in obese subjects, the more classical evoked being based on sequestration and/or dilution of VD in adipose tissue (AT), the main VD storage site. However, this mechanism has never been demonstrated. In order to confirm this hypothesis, the concentration of VD and its metabolites in adipose tissue need to be quantified. The objective of this study is to determine the concentration of VD and its metabolites in adipose tissue as well as adipose tissue mass quantification and distribution (visceral or subcutaneous) to highlight putative difference of VD and its metabolites quantities between obese and non-obese patients. A quantification of VD metabolism, inflammation and lipid metabolism gene expression will be realized on biopsies. Correlations between gene expression and quantity of VD in tissue will be carrying out.
CONDITIONS
Official Title
Vitamin D and Its Metabolites Quantification in Adipose Tissues of Obese and Non-obese Patients.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Body mass index (BMI) greater than 35 kg/m2 (obese group) or less than 30 kg/m2 (non-obese group)
- Undergoing bariatric surgery if obese or abdominal surgery if non-obese
You will not qualify if you...
- Regular use of dietary or vitamin supplements in the last three months
- For non-obese group: malnourished patients (BMI less than 18.5 kg/m2, weight loss over 5% in 1 month or 10% in 6 months)
- For non-obese group: presence of infection or inflammatory syndrome (CRP over 10 mg/L and/or white blood cells over 12000/mm3)
- For non-obese group: cancer diagnosis
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Assistance Publique Hôpitaux de Marseille
Marseille, France, 13005
Actively Recruiting
Research Team
R
Rene VALERO
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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