Actively Recruiting
Role of Vitamin D in Prevention of Preeclampsia Recurrence in Pregnant Women With Previous History of Preeclampsia: A Randomized Controlled Trial
Led by Nishtar Medical University · Updated on 2025-12-17
146
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This clinical trial investigates whether giving vitamin D supplements to pregnant women who had pre-eclampsia in a previous pregnancy can help prevent the condition from returning. The study aims to find out if vitamin D reduces the chance of recurrent pre-eclampsia in this group of women. Pregnant women attending the antenatal clinic at Nishtar Hospital Multan are invited to participate in this research. Participants will be randomly assigned to one of two groups. One group will take 4,000 IU of oral vitamin D daily until 36 weeks of pregnancy. The other group will receive a placebo pill that looks, tastes, and feels the same but contains no vitamin D. Each woman will visit the clinic every two weeks during the study period. During each visit, blood pressure will be checked, and if it reaches 140/90 mmHg or higher, a urine test will be done to check for protein, which helps identify pre-eclampsia. If pre-eclampsia is diagnosed, standard care will be provided and recorded. The main outcome is to compare how many women in each group develop recurrent pre-eclampsia by 36 completed weeks of pregnancy.
CONDITIONS
Brief Title
Vitamin D for Preventing Recurrent Preeclampsia in Pregnant Women
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Gestational age of 20 weeks or more (based on last menstrual period)
- Past medical history of pre-eclampsia
- Female participants aged between 20 and 45 years
You will not qualify if you...
- Pre-existing hypertension, cardiac diseases, renal disease, or thyrotoxicosis as noted in medical history or records
- Women presenting with intra-uterine fetal death in the current pregnancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - From enrollment until 36 completed weeks of gestation
Participants take either vitamin D or placebo orally once daily until 36 weeks of gestation.
Regular visits as per study schedule until 36 weeks of gestation
Trial Site Locations
Total: 1 location
1
Nishtar Medical University and Hospital
Multan, Punjab Province, Pakistan, 60000
Actively Recruiting
Research Team
T
Tehseen A Principal Investigator, MBBS
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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