Actively Recruiting

Phase 4
Age: 20Years - 45Years
FEMALE
NCT07288801

Vitamin D for Preventing Recurrent Preeclampsia in Pregnant Women

Led by Nishtar Medical University · Updated on 2025-12-17

146

Participants Needed

1

Research Sites

26 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

The goal of this clinical trial is to find out whether giving vitamin D to pregnant women who had pre-eclampsia in a previous pregnancy helps prevent the condition from coming back. The main question it aims to answer is: Does vitamin D supplementation reduce the chance of pre-eclampsia recurring in pregnant women with a history of pre-eclampsia? To answer this question, pregnant women attending the antenatal clinic at the Department of Obstetrics and Gynaecology, Nishtar Hospital Multan will be invited to join the study. Participants will be randomly assigned to two equal groups: * Vitamin D group: will take 4,000 IU of oral vitamin D until 36 weeks of gestation. * Placebo group: will receive a pill identical in appearance, taste, and consistency but without vitamin D. While on the study medication, each woman will visit the clinic every two weeks. At each visit, her blood pressure will be measured, and if it is 140/90 mmHg or higher, a urine test will check for protein to identify pre-eclampsia as per hospital protocol. Any diagnosis of pre-eclampsia will lead to standard care, and the outcome will be recorded. At the end, researchers will compare how many women in each group developed recurrent pre-eclampsia. This study will help answer whether vitamin D supplementation can safely reduce the risk of pre-eclampsia returning in women with a prior history - a question important for improving pregnancy outcomes and maternal health.

CONDITIONS

Official Title

Vitamin D for Preventing Recurrent Preeclampsia in Pregnant Women

Who Can Participate

Age: 20Years - 45Years
FEMALE

Eligibility Criteria

Eligible

You may qualify if you...

  • Pregnant women with a gestational age of 20 weeks or more (based on last menstrual period)
  • History of pre-eclampsia in a previous pregnancy
Not Eligible

You will not qualify if you...

  • History of pre-existing hypertension, cardiac diseases, kidney disease, or thyrotoxicosis
  • Women with fetal death during the current pregnancy

AI-Screening

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Trial Site Locations

Total: 1 location

1

Nishtar Medical University and Hospital

Multan, Punjab Province, Pakistan, 60000

Actively Recruiting

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Research Team

T

Tehseen A Principal Investigator, MBBS

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

DOUBLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

PREVENTION

Number of Arms

2

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