Actively Recruiting
Vitamin D Status and Multi-Omics Profiles in Primary Osteoporosis
Led by Dr. Li Chen · Updated on 2025-12-22
120
Participants Needed
1
Research Sites
107 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This observational study aims to explore the relationships between vitamin D status and genomic, proteomic, and metabolomic profiles in patients with primary osteoporosis. Eligible participants are adults who are newly diagnosed with primary osteoporosis at Yichang Second People's Hospital. Blood samples will be collected at the initial diagnosis to analyze gene expression, protein levels, and metabolic profiles. Participants will receive standard clinical treatment according to routine care, but no additional research sampling or follow-up will be performed. The study seeks to identify molecular patterns associated with osteoporosis and improve understanding of patient responses to therapy.
CONDITIONS
Official Title
Vitamin D Status and Multi-Omics Profiles in Primary Osteoporosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 years or older with normal bone mineral density and no history of bone metabolic diseases, major organ dysfunction, or chronic inflammatory/autoimmune diseases (healthy controls)
- Adults aged 18 years or older newly diagnosed with primary osteoporosis (T-score 2.5 SD or below by DXA) without serious complications
- Willing and able to provide written informed consent and cooperate with study procedures including blood and serum sample collection and clinical data recording
You will not qualify if you...
- Patients with secondary osteoporosis caused by conditions such as hyperparathyroidism, tumors, chronic kidney disease, liver cirrhosis, rheumatoid arthritis, or other autoimmune diseases
- Individuals who have taken vitamin D supplements, anti-osteoporotic drugs, glucocorticoids, or other medications affecting vitamin D or bone metabolism within 3 months before enrollment
- Pregnant or lactating women or those with mental disorders preventing cooperation with study procedures
- Individuals with acute infections, malignant tumors, or severe liver, kidney, cardiovascular, or cerebrovascular diseases that may affect study results
- Participants with a history of blood transfusion within 1 month before enrollment or unable to provide peripheral blood samples as required
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Yichang Second People's Hospital
Yichang, Hubei, China, 443000
Actively Recruiting
Research Team
L
Li Chen, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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