Actively Recruiting

Phase 4
Age: 18Years +
All Genders
NCT07515664

Vitamin K for Perioperative Warfarin Management

Led by University of Michigan · Updated on 2026-04-13

20

Participants Needed

1

Research Sites

56 weeks

Total Duration

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Sponsors

U

University of Michigan

Lead Sponsor

N

National Heart, Lung, and Blood Institute (NHLBI)

Collaborating Sponsor

AI-Summary

What this Trial Is About

This is a feasibility study of uninterrupted warfarin with a one time dose of Vitamin K before a surgical procedure.

CONDITIONS

Official Title

Vitamin K for Perioperative Warfarin Management

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Warfarin therapy for 63 months
  • Use of home INR testing equipment
  • Scheduled for a surgical procedure that requires INR 64 1.5 (typically achieved with warfarin interruption)
  • INR 64 4 on day 7-10 prior to procedure
Not Eligible

You will not qualify if you...

  • Surgical procedure does not require INR 61.5 (typically achieved with warfarin interruption)
  • Surgical procedure with a high risk of bleeding or complications (urologic procedures, bronchoscopy, epidural injections, nerve blocks, spinal surgery)
  • Warfarin therapy for �3 months
  • Lack of English language proficiency
  • Use of a Heartmate II or HVAD left ventricular assist device
  • Recent thrombotic event (within 3 months)
  • CHA2DS2-VASc score 6 6
  • INR 6 4 on day 7-10 prior to procedure
  • Hypersensitivity to any component of Vitamin K or simple syrup (used in the compounding process)

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Michigan Medicine

Ann Arbor, Michigan, United States, 48109

Actively Recruiting

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Research Team

G

Geoffrey Barnes, MD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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