Study of Daily Vitamin B6, B9, B12, and Choline Supplementation to Support Eye Health in Adults with Open-Angle or Pseudoexfoliation Glaucoma

What this Trial Is About

This research aims to evaluate whether a combination of vitamins B6, B9, B12, and choline can help protect the eyes and slow vision loss in adults with glaucoma, including primary open-angle glaucoma, normal-tension glaucoma, and pseudoexfoliation glaucoma. The study focuses on whether these vitamins support retinal cells and maintain or improve their function alongside standard glaucoma care. Participants will be randomly assigned to one of two groups. One group will take a daily vitamin B-mix supplement along with their usual glaucoma treatment for one year, while the other group will continue with standard care without extra vitamins. The vitamin doses are selected to be well tolerated, with possible mild side effects such as upset stomach or tingling sensations. The study involves five clinic visits over 12 months, with eye tests, scans of the nerve layers, electroretinograms to assess retinal function, and blood sample collection. Participants will have routine eye pressure checks, vision and visual field tests, and scans at the start and every three months until the end of the study. Researchers will measure changes in retinal function using electroretinography, retinal structure, visual field indices, eye pressure, visual acuity, and blood biomarkers. The study includes monitoring for safety and adherence throughout the 12 months, providing a comprehensive evaluation of the vitamin mix as a possible additional approach to reduce vision loss in glaucoma patients.

Vitamin Mix (B6, B9, B12, And Choline) For Glaucoma Patients