Actively Recruiting
In Vitro Organoid Drug Sensitivity-Guided Treatment for Advanced Pancreatic Neuroendocrine Tumor
Led by Ruijin Hospital · Updated on 2024-05-16
20
Participants Needed
1
Research Sites
116 weeks
Total Duration
On this page
Sponsors
R
Ruijin Hospital
Lead Sponsor
C
Chongqing Kingbiotech Co.,Ltd
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to explore whether chemotherapy and targeted-therapy regimens guided by organoid drug sensitivity test can improve the outcomes of non-resectable locally advanced and metastatic Pancreatic neuroendocrine tumors. At the same time, this study will evaluate the successful stablishment rate of organoid from biopsy tissue , and explore the concordance between drug sensitivity test results and patients' treatment response
CONDITIONS
Official Title
In Vitro Organoid Drug Sensitivity-Guided Treatment for Advanced Pancreatic Neuroendocrine Tumor
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 to 75 years old
- Histologically or cytologically confirmed locally advanced or metastatic pancreatic neuroendocrine tumor
- Surgery is impossible or not aimed at radical cure
- Able to provide fresh tumor tissue specimens for organoid culture
- Eastern Cooperative Oncology Group (ECOG) performance status score of 0 to 2
- Expected survival time of at least six months
- Informed consent given and able to comply with follow-up requirements
You will not qualify if you...
- Other malignancies within the past 5 years, except cured basal cell carcinoma of the skin
- Severe cardiovascular events or myocardial infarction within 12 months before the study
- Psychiatric disorders or substance abuse with inability to abstain
- Pregnant or breastfeeding women
- Other serious systemic diseases or conditions that make participation unsuitable according to the researcher
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Ruijin Hospital Shanghai Jiaotong University School of Medicine
Shanghai, Shanghai Municipality, China, 200025
Actively Recruiting
Research Team
J
Jiabin JIN, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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