Actively Recruiting
Voice Analysis Using Artificial Intelligence to Detect Changes in Pulmonary Arterial Pressure in Patients With Heart Failure and an Implanted Pressure Sensor
Led by Noah Labs · Updated on 2026-03-02
60
Participants Needed
3
Research Sites
17 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating whether daily voice recordings analyzed by artificial intelligence can detect changes in pulmonary arterial pressure in heart failure patients with implanted pressure sensors. This observational study involves patients from multiple centers in Germany and the United States who have heart failure and implanted PA pressure sensors like CardioMEMS or Cordella. The goal is to assess if voice analysis can serve as a non-invasive alternative for monitoring changes in pulmonary congestion related to heart failure. Participants record daily voice samples, including sustained vowel sounds and a standardized reading passage, using a mobile app for 12 weeks. During this time, they continue their standard care and routine PA pressure monitoring with their implanted sensors. The voice recordings and pressure data are collected daily but analyzed retrospectively after the study is completed, meaning no clinical decisions are made based on voice analysis during the trial. Throughout the study, participants will provide daily voice recordings via the app while their PA pressure readings are collected per usual care. Researchers will evaluate the sensitivity and specificity of the AI-based voice analysis in detecting PA pressure changes, along with adherence to daily recording and the relationship between voice predictions and clinical events. There are no additional clinical visits required, and the study participation lasts for 12 weeks.
CONDITIONS
Brief Title
Voice Analysis to Detect Pulmonary Arterial Pressure Changes in Heart Failure
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Successful implantation of a pulmonary arterial pressure sensor monitored by a participating study center
- Willingness to record a short predefined text daily for 3 months using a smartphone or tablet
- Ability to comfortably read aloud the study passage in English or German
- Signed informed consent obtained
You will not qualify if you...
- Pregnant, breastfeeding, or unwilling to practice birth control during participation
- Conditions that may compromise safety or data quality as judged by the investigator
- Pathological voice changes due to surgery or injury
- Planned invasive cardiac procedures during the study period
- COPD requiring home oxygen therapy
- Chronic kidney disease requiring dialysis
- Cognitive dysfunction limiting ability to perform daily voice recording
- Inability to read English or German
- Physical inability to use the recording device
Research Team
L
Leonhard Riehle, MD
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here