Actively Recruiting
Voice Analysis to Detect Pulmonary Arterial Pressure Changes in Heart Failure
Led by Noah Labs · Updated on 2026-03-02
60
Participants Needed
3
Research Sites
89 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
VAPP-HF is a prospective, multi-center, observational study assessing whether daily voice recordings analyzed by a machine learning algorithm can detect changes in pulmonary arterial (PA) pressure in heart failure patients with implanted PA pressure sensors (e.g., CardioMEMS, Cordella). Patients across three sites in Germany and the United States provide daily voice recordings via a mobile app for 12 weeks while continuing standard PA pressure monitoring and heart failure care. Voice data is analyzed retrospectively after study completion; no clinical decisions are based on voice analysis during the study. The primary endpoint is the sensitivity and specificity of the AI-based voice analysis in detecting PA pressure changes at defined thresholds.
CONDITIONS
Official Title
Voice Analysis to Detect Pulmonary Arterial Pressure Changes in Heart Failure
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Successful implantation of a PA pressure sensor and monitored by a participating study center
- Willingness to record a short predefined text daily for 3 months using a smartphone or tablet
- Ability to comfortably read aloud the study passage in English or German
- Written informed consent obtained
You will not qualify if you...
- Pregnant, breastfeeding, or unwilling to practice birth control during participation
- Condition that in the opinion of the investigator would compromise patient safety or data quality
- Pathological voice changes due to surgery or injury
- Planned invasive cardiac procedures during the study period
- COPD requiring home oxygen therapy
- Chronic kidney disease requiring dialysis
- Cognitive dysfunction limiting ability to perform daily voice recording
- Inability to read English or German
- Physical inability to use the recording device
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
University of California, San Francisco (UCSF)
San Francisco, California, United States, 94143
Actively Recruiting
2
BG Klinikum Unfallkrankenhaus Berlin, Dept. of Cardiology
Berlin, State of Berlin, Germany, 12683
Completed
3
University Hospital Frankfurt, Dept. of Cardiology and Angiology
Frankfurt, Germany, 60590
Completed
Research Team
L
Leonhard Riehle, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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